Abstract

Murine models have been extensively utilized by Washington University Digestive Diseases Research Core Center investigators and are central to DDRCC biomedical research into inflammatory bowel disease and other aspects of the digestive system. The Murine Models Core has been and will continue to be dedicated to producing genetically altered animals and to providing gnotobiotic mice for DDRCC investigators in a timely and reliable manner. In addition, the Core provides ancillary sen/ices for maintaining mouse pedigrees, such as assisted reproduction and cryopreservation of embryos, as well as rapid transfer of mutations or transgenes from one genetic background to another using """"""""speed congenics"""""""". We will continue to offer these services in the next project period.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK052574-15
Application #
8574509
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
15
Fiscal Year
2014
Total Cost
$118,439
Indirect Cost
$40,519

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Luo, Jialie; Qian, Aihua; Oetjen, Landon K et al. (2018) TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells. Immunity 49:107-119.e4
Nywening, Timothy M; Belt, Brian A; Cullinan, Darren R et al. (2018) Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma. Gut 67:1112-1123
Liss, Kim H H; McCommis, Kyle S; Chambers, Kari T et al. (2018) The impact of diet-induced hepatic steatosis in a murine model of hepatic ischemia/reperfusion injury. Liver Transpl 24:908-921
Anderson, Neil W; Tarr, Phillip I (2018) Multiplex Nucleic Acid Amplification Testing to Diagnose Gut Infections: Challenges, Opportunities, and Result Interpretation. Gastroenterol Clin North Am 47:793-812
Yoshino, Jun; Almeda-Valdes, Paloma; Moseley, Anna C et al. (2018) Percutaneous muscle biopsy-induced tissue injury causes local endoplasmic reticulum stress. Physiol Rep 6:e13679
Stoka, Kellie V; Maedeker, Justine A; Bennett, Lisa et al. (2018) Effects of Increased Arterial Stiffness on Atherosclerotic Plaque Amounts. J Biomech Eng 140:
Kulkarni, Devesha H; McDonald, Keely G; Knoop, Kathryn A et al. (2018) Goblet cell associated antigen passages are inhibited during Salmonella typhimurium infection to prevent pathogen dissemination and limit responses to dietary antigens. Mucosal Immunol 11:1103-1113
Sofia, M Anthony; Ciorba, Matthew A; Meckel, Katherine et al. (2018) Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis. Inflamm Bowel Dis 24:1471-1480
Onufer, Emily J; Tay, Shirli; Barron, Lauren K et al. (2018) Intestinal epithelial cell-specific Raptor is essential for high fat diet-induced weight gain in mice. Biochem Biophys Res Commun 505:1174-1179
Bajpai, Geetika; Schneider, Caralin; Wong, Nicole et al. (2018) The human heart contains distinct macrophage subsets with divergent origins and functions. Nat Med 24:1234-1245

Showing the most recent 10 out of 899 publications