The overarching goal of the Washington University Digestive Disease Research Core Center, (WU-DDRCC) is to assist investigators exploring the foundations of host-environment interactions in the pathophysiology of digestive diseases. The WU-DDRCC seeks to advance the health of patients with digestive diseases by supporting enabling technology and promoting the basic and translational research interests of its 49 Full + 11 Associate members, he DDRCC promotes the expertise and interests of the Research Base in a comprehensive program that is strategically aligned with the distinguishing institutional strengths in human genetics and the microbiome. The Center is justified by the needs of its members and has adapted to provide core support and enabling technology that expands members' research capacity through core laboratories that provide training, technical support and a unique centralized resource for organization of clinical metadata and biospecimens. In addition, the Center provides a Pilot/Feasibility Program that offers start up and support to junior investigators wishing to pursue digestive disease research. Finally, the Center has a scientific Enrichment Program that supports lectures and workshops by visiting scientists and promotes interactions and collaborations among the members. The WU-DDRCC includes 49 Full members with overall TDCs of $23.8M. The Research Base includes investigators whose interests span three major areas, specifically (1) Host-microbial interactions/inflammations/mucosal immunity; (2) Stem cell biology/development/epithelial renewal/cancer biology; (3) Nutrient transport/metabolism/ signaling. The research interests of the Full members/Research Base are approximately equally represented among these three broad categories while simultaneously maintaining a strong focus on host-environmental factors in digestive disease. The WU-DDRCC includes four Cores, including an Administrative and Resource Access Core (ARAC), a Biobank Core, a Murine Models Core and an Advanced Imaging and Tissue Analysis Core. In addition, the WU-DDRCC has an active Enrichment Program and a Pilot/Feasibility Program that has supported and nurtured new investigators as they transition to scientific independence.

Public Health Relevance

Research supported through the WU DDRCC has and will continue to have a profound impact on understanding the pathophysiology of digestive disease and the role of host-environment interactions. The WU DDRCC also promotes scientific collaboration and synergies that ultimately will identify new therapeutic opportunities with the potential for rapid translation into clinical trials for patients with digestive diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
Program Officer
Perrin, Peter J
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Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
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Luo, Jialie; Feng, Jing; Yu, Guang et al. (2018) Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. J Allergy Clin Immunol 141:608-619.e7
Tarr, Gillian A M; Oltean, Hanna N; Phipps, Amanda I et al. (2018) Strength of the association between antibiotic use and hemolytic uremic syndrome following Escherichia coli O157:H7 infection varies with case definition. Int J Med Microbiol 308:921-926
Brenot, Audrey; Knolhoff, Brett L; DeNardo, David G et al. (2018) SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion. Oncogenesis 7:32
Kumar, Pardeep; Kuhlmann, F Matthew; Chakraborty, Subhra et al. (2018) Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity. J Clin Invest 128:3298-3311
Baumann-Dudenhoeffer, Aimee M; D'Souza, Alaric W; Tarr, Phillip I et al. (2018) Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes. Nat Med 24:1822-1829
Bockerstett, Kevin A; Wong, Chun Fung; Koehm, Sherri et al. (2018) Molecular Characterization of Gastric Epithelial Cells Using Flow Cytometry. Int J Mol Sci 19:
Smith, Gordon I; Commean, Paul K; Reeds, Dominic N et al. (2018) Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study. Obesity (Silver Spring) 26:854-861
Rubin, Deborah C (2018) CFTR and the Regulation of Crypt Cell Proliferation. Cell Mol Gastroenterol Hepatol 5:418-419
Porter, Lane C; Franczyk, Michael P; Pietka, Terri et al. (2018) NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism. Am J Physiol Endocrinol Metab 315:E520-E530
Azar, Christopher; Valentine, Mark; Trausch-Azar, Julie et al. (2018) RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts. Sci Rep 8:5142

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