Vector Core The Vector Core at the University of Iowa is integrated into multiple gene therapy projects directed at the study of diseases of the lung, eye, brain, liver, heart and muscle, as well as at the study of the cardiovascular and neuromuscular systems. Also, Vector Core staff are active participants in the development of gene transfer technologies used by the Cardiovascular, Macular Degeneration, and Cystic Fibrosis Centers. The resulting interaction with multiple investigators from various disciplines allows for cross-fertilization of ideas, technical advancements, and innovations in vector designs. The overall objective of the Vector Core facility is to support investigators in the use of gene transfer technologies. This includes consultation with the Principle Investigator and staff, development of novel vectors, collaborative testing of the vectors generated for function and purity, and routine preparation of vectors (including quality control). The Vector Core staff and investigators are in close contact through all phases of vector design and generation. Thus, the Core serves both as a research and development facility for gene transfer studies and a service facility for routine vector preparation. As a part of its service, the Vector Core provides purified and concentrated preparations of recombinant adenovirus, adeno-associated virus (AAV), and retrovirus (including lentivirus). This facility will also provide access to standard cell lines, expression plasmids, and stocks of recombinant reporter viruses. The main responsibilities of the Core will be: Preparation of recombinant vectors Dissemination of vectors Maintainance of database of available vector stocks Maintainance of database of available expression vectors; development of new expression vectors Development of novel methods for virus production Consultation on and assistance in the design and development of novel vectors

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK054759-14
Application #
8564798
Study Section
Special Emphasis Panel (ZDK1-GRB-1 (J2))
Project Start
1998-09-30
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
14
Fiscal Year
2012
Total Cost
$178,081
Indirect Cost
$60,792
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
McCullagh, Brian N; Comellas, Alejandro P; Ballas, Zuhair K et al. (2017) Antibody deficiency in patients with frequent exacerbations of Chronic Obstructive Pulmonary Disease (COPD). PLoS One 12:e0172437
Gariepy, Cheryl E; Heyman, Melvin B; Lowe, Mark E et al. (2017) Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group. J Pediatr Gastroenterol Nutr 64:95-103
Sinn, P L; Hwang, B-Y; Li, N et al. (2017) Novel GP64 envelope variants for improved delivery to human airway epithelial cells. Gene Ther 24:674-679
Mangalam, Ashutosh; Shahi, Shailesh K; Luckey, David et al. (2017) Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease. Cell Rep 20:1269-1277
Wang, Zekun; Shen, Weiran; Cheng, Fang et al. (2017) Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication. J Virol 91:
Aaron, Carrie P; Schwartz, Joseph E; Hoffman, Eric A et al. (2017) A Longitudinal Cohort Study of Aspirin Use and Progression of Emphysema-like Lung Characteristics on CT Imaging: The MESA Lung Study. Chest :
Haghighi, Babak; D Ellingwood, Nathan; Yin, Youbing et al. (2017) A GPU-based symmetric non-rigid image registration method in human lung. Med Biol Eng Comput :
Swatek, Anthony M; Lynch, Thomas J; Crooke, Adrianne K et al. (2017) Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis. Am J Respir Crit Care Med :
Hoffman, Eric A; Weibel, Ewald R (2017) Multiscale Lung Imaging Provides New Insights into Disease Progression in the Chronic Obstructive Pulmonary Disease Lung. Am J Respir Crit Care Med 195:551-552
Stewart, Elizabeth J; Payne, David E; Ma, Tianhui Maria et al. (2017) Effect of Antimicrobial and Physical Treatments on Growth of Multispecies Staphylococcal Biofilms. Appl Environ Microbiol 83:

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