Administrative Core The Administrative Core, consisting of the Center Director, Associate Director, and an Administrator, acts under the supervision of the Center Executive Committee. This Core has coordinated and overseen many different aspects of this Gene Therapy Core Center, including financial documentation and accountability for the Center, membership and recruitment, scientific enrichment programs such as external speaker seminars and a weekly Gene Therapy Seminar series, recruitment and external reviews of pilot and feasibility applications, solicitation and compilation of annual Core evaluations, the annual Gene Therapy Center retreat, and maintenance of the Gene Therapy web site and the members'information database. A primary function of the Administrative Core will be to implement decisions made by the Executive Committee in order to ensure that the goals of the Gene Therapy Center are achieved. Scientific functions of the Core include evaluation of the services offered by the Research Cores and the solicitation, external review, and monitoring of pilot and feasibility projects. The Administrative Core also maintains detailed records of investigator usage by the Research Cores and oversees recharge for services. The quality and timeliness of core services is also monitored on an annual basis through investigator questionnaires as well as informally throughout the year. Scientific enrichment programs administered by this Core include: a weekly Gene Therapy Seminar series where post-docs, graduate students, junior investigators, pilot holders, and external speakers present their research;specialized internal and external speaker seminars co-sponsored by other pulmonary groups on campus;journal and discussion clubs;an up-to-date web site which highlights the latest achievements and research of Center investigators, research core services, and other Center activities;an annual retreat as a forum for external review of the pilot program and Center;visits of select expert external reviewers throughout the year who also present seminars on special topics. The Core also maintains a members'information database that compiles research profiles, biographical sketches, manuscripts and grant support on investigators of the Center, and it is accessible by members and administrators through a secure on-line web interface on the Center's web site. The Director and Administrator of the Center review budget summary reports for each of the Research Cores on a quarterly basis. Any rebudgeting requires approval of the Center Director and/or the Executive Committee, depending on the magnitude of the proposed reappropriated funds. The Administrative Core also assists in the oversight of the CF Lung Tissue Acquisition Program through interactions with the Cells and Tissue Core Director, and oversees consortium pilot subcontracts with outside institutions involved in this Tissue Acquisition Program

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Iowa
Iowa City
United States
Zip Code
Weldon, Sinéad; McNally, Paul; McAuley, Danny F et al. (2014) miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. Am J Respir Crit Care Med 190:165-74
Sui, Hongshu; Yi, Yaling; Yao, Jianrong et al. (2014) Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets. PLoS One 9:e90519
Xie, Weiliang; Lynch, Thomas J; Liu, Xiaoming et al. (2014) Sox2 modulates Lef-1 expression during airway submucosal gland development. Am J Physiol Lung Cell Mol Physiol 306:L645-60
Hoegger, Mark J; Awadalla, Maged; Namati, Eman et al. (2014) Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs. Proc Natl Acad Sci U S A 111:2355-60
Sun, Xingshen; Olivier, Alicia K; Yi, Yaling et al. (2014) Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets. Am J Pathol 184:1309-22
Keiser, Megan S; Boudreau, Ryan L; Davidson, Beverly L (2014) Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapy. Mol Ther 22:588-95
Gu, Xiaoling; Karp, Philip H; Brody, Steven L et al. (2014) Chemosensory functions for pulmonary neuroendocrine cells. Am J Respir Cell Mol Biol 50:637-46
Peng, Xinxia; Alföldi, Jessica; Gori, Kevin et al. (2014) The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease. Nat Biotechnol 32:1250-5
Swiderski, Ruth E; Nakano, Yoko; Mullins, Robert F et al. (2014) A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. PLoS Genet 10:e1004689
Schultz, Mark L; Tecedor, Luis; Stein, Colleen S et al. (2014) CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events. PLoS One 9:e96647

Showing the most recent 10 out of 301 publications