Administrative Core The Administrative Core, consisting of the Center Director, Associate Director, and an Administrator, acts under the supervision of the Center Executive Committee. This Core has coordinated and overseen many different aspects of this Gene Therapy Core Center, including financial documentation and accountability for the Center, membership and recruitment, scientific enrichment programs such as external speaker seminars and a weekly Gene Therapy Seminar series, recruitment and external reviews of pilot and feasibility applications, solicitation and compilation of annual Core evaluations, the annual Gene Therapy Center retreat, and maintenance of the Gene Therapy web site and the members'information database. A primary function of the Administrative Core will be to implement decisions made by the Executive Committee in order to ensure that the goals of the Gene Therapy Center are achieved. Scientific functions of the Core include evaluation of the services offered by the Research Cores and the solicitation, external review, and monitoring of pilot and feasibility projects. The Administrative Core also maintains detailed records of investigator usage by the Research Cores and oversees recharge for services. The quality and timeliness of core services is also monitored on an annual basis through investigator questionnaires as well as informally throughout the year. Scientific enrichment programs administered by this Core include: a weekly Gene Therapy Seminar series where post-docs, graduate students, junior investigators, pilot holders, and external speakers present their research;specialized internal and external speaker seminars co-sponsored by other pulmonary groups on campus;journal and discussion clubs;an up-to-date web site which highlights the latest achievements and research of Center investigators, research core services, and other Center activities;an annual retreat as a forum for external review of the pilot program and Center;visits of select expert external reviewers throughout the year who also present seminars on special topics. The Core also maintains a members'information database that compiles research profiles, biographical sketches, manuscripts and grant support on investigators of the Center, and it is accessible by members and administrators through a secure on-line web interface on the Center's web site. The Director and Administrator of the Center review budget summary reports for each of the Research Cores on a quarterly basis. Any rebudgeting requires approval of the Center Director and/or the Executive Committee, depending on the magnitude of the proposed reappropriated funds. The Administrative Core also assists in the oversight of the CF Lung Tissue Acquisition Program through interactions with the Cells and Tissue Core Director, and oversees consortium pilot subcontracts with outside institutions involved in this Tissue Acquisition Program

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Iowa
Iowa City
United States
Zip Code
Vargas Buonfiglio, Luis G; Borcherding, Jennifer A; Frommelt, Mark et al. (2018) Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance. Respir Res 19:42
Fricke, Erin M; Elgin, Timothy G; Gong, Huiyu et al. (2018) Lipopolysaccharide-induced maternal inflammation induces direct placental injury without alteration in placental blood flow and induces a secondary fetal intestinal injury that persists into adulthood. Am J Reprod Immunol 79:e12816
Mao, Suifang; Shah, Alok S; Moninger, Thomas O et al. (2018) Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling. Proc Natl Acad Sci U S A 115:1370-1375
Dunican, Eleanor M; Elicker, Brett M; Gierada, David S et al. (2018) Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest 128:997-1009
Liu, Chia-Ying; Parikh, Megha; Bluemke, David A et al. (2018) Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study. J Magn Reson Imaging 47:262-271
Bodduluri, Sandeep; Reinhardt, Joseph M; Hoffman, Eric A et al. (2018) Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 15:281-289
Xie, Yuliang; Ostedgaard, Lynda; Abou Alaiwa, Mahmoud H et al. (2018) Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways. Ann Am Thorac Soc 15:S171-S176
Yan, Ziying; Zou, Wei; Feng, Zehua et al. (2018) Establishment of a High Yield rAAV/HBoV Vector Production System Independent of Bocavirus Non-structural Proteins. Hum Gene Ther :
Taher, Hisham; Bauer, Christian; Abston, Eric et al. (2018) Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs. J Appl Physiol (1985) 124:1186-1193
Luehrs, Rachel E; Newell Jr, John D; Comellas, Alejandro P et al. (2018) CT-Measured Lung Air-Trapping is Associated with Higher Carotid Artery Stiffness in Individuals with Chronic Obstructive Pulmonary Disease. J Appl Physiol (1985) :

Showing the most recent 10 out of 669 publications