We request renewed funding to continue the documented success achieved by UAB's Nutrition Obesity Research Center (NORC) in its first two funding cycles. Inaugurated with NIH funding in 2000, our NORC fosters multidisciplinary, collaborative basic clinical and translational nutrition and obesity research. Since it was first funded, the NORC's research base has grown substantially. At inception (2000), we had 60 members;this number increased 70% to 102 members in 2006 at our last renewal and another 31% to 134 members in 2011. In 2000, our members held as Pis 15 R01s or K-awards that were clearly related to nutrition or obesity;this number increased 93% to 29 such grants active in 2006 and another 17% to 34 (including ROD grants) active in 2011 (as of this writing). UAB's NORC has directly helped to recruit at least a dozen new and established obesity and nutrition investigators in the past funding cycle. Our publication output has steadily increased in absolute numbers and as a proportion of the world's literature on obesity and nutrition. The impact of NORC publications as judged by citation counts consistently exceeds the norm for peer-reviewed literature on obesity and nutrition. Our NORC leadership oversees two NIH-funded T32 training grants for obesity research, an industry-sponsored obesity training grant, and a series of national nutrition and obesity-related conferences. Our NORC funds at least four P/F studies per year, a Named New Investigator, and an extensive Enrichment Program. UAB provides our NORC over $700,000 annually to supplement the NIDDK P30 grant. The NORC Cores in Metabolism/Body Composition, Genomics, Animal Models, and Biostatistics have flourished, resulting in cost-effective research and enhanced access to cutting-edge technology that is heavily utilized by our members. Our primary theme is Obesity: Causes, Consequences, and Alleviation. Within this broad multidisciplinary theme, we are cultivating subdomains such as obesity among minorities and health disparities;obesity, caloric restriction, and aging;developmental and pediatric aspects;and mathematical/quantitative science approaches. Backed by exceptional institutional support and academic infrastructure, we request renewed funding to continue our contributions to this important area of research.
One's nutritional intake can have profound positive or negative consequences on health. So too does obesity, or excess body fat, have profound effects, usually negative, on health, quality of life, and lifespan. Beyond these broad generalities, however, much remains unknown in these domains, and misinformation and superstition abound. Our center advances knowledge on these critical contributors to health and disease through scientific inquiry that is both rigorous and creative.
|Kyle, Theodore K; Dhurandhar, Emily J; Allison, David B (2016) Regarding Obesity as a Disease: Evolving Policies and Their Implications. Endocrinol Metab Clin North Am 45:511-20|
|Kaiser, Kathryn A; Parman, Mariel A; Kim, Eric et al. (2016) Potential Errors and Omissions Related to the Analysis and Conclusions Reported in Cuspidi C, et al., AJH 2014; 27(2):146-156. Am J Hypertens 29:780-1|
|Lewis Jr, D W; Fields, D A; Allison, D B (2016) Inconsistencies and inaccuracies in reporting on choice of endpoints and of statistical results in RCT of maternal diet. Pediatr Obes 11:e16-e17|
|Liu, Jian; Wang, Peipei; Douglas, Samuel L et al. (2016) Impact of high-fat, low-carbohydrate diet on myocardial substrate oxidation, insulin sensitivity, and cardiac function after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 311:H1-H10|
|Frihauf, Jennifer B; Fekete, Eva M; Nagy, Tim R et al. (2016) Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers. Am J Physiol Regul Integr Comp Physiol :ajpregu.00023.2016|
|Milner, Adrienne N; George, Brandon J; Allison, David B (2016) Black and Hispanic Men Perceived to Be Large Are at Increased Risk for Police Frisk, Search, and Force. PLoS One 11:e0147158|
|Joseph, Rodney P; Pekmezi, Dori; Dutton, Gareth R et al. (2016) Results of a Culturally Adapted Internet-Enhanced Physical Activity Pilot Intervention for Overweight and Obese Young Adult African American Women. J Transcult Nurs 27:136-46|
|Heyward, Frankie D; Gilliam, Daniel; Coleman, Mark A et al. (2016) Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. J Neurosci 36:1324-35|
|Roth, David L; Skarupski, Kimberly A; Crews, Deidra C et al. (2016) Distinct age and self-rated health crossover mortality effects for African Americans: Evidence from a national cohort study. Soc Sci Med 156:12-20|
|Reese, Jasmine M; Joseph, Rodney P; Cherrington, Andrea et al. (2016) Development of Participant-Informed Text Messages to Promote Physical Activity Among African American Women Attending College: A Qualitative Mixed-Methods Inquiry. J Transcult Nurs :|
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