This revised application is submitted in response to RFA DK-99-017, Silvio O. Conte Digestive Disease Research Core Center requesting establishment of a Texas Gulf Coast Digestive Diseases Center (called DDC for simplicity). This Center will serve basic and clinical scientists at institutions within the Texas Medical Center (Baylor College of Galveston. Our qualifying Funded Research Base is $9,031, 281 million (direct costs) and includes 34 separate awards from NIDDK totaling in excess of $4,647,452 million (direct costs). Reflecting the goals of these projects, we propose to establish a Center for Gastrointestinal Development, Infection and Injury. This application has developed from a core group of investigators who began interacting formally in 1996 to explore the need and interest in establishing a Center. These interactions were initiated by a Pediatric Training Program in Gastroenterology at Baylor whose faculty now represent key investigators in our proposed Center. Institutional resource commitments in space, funds and personnel support this effort. New positions in both pediatric and adult Gastroenterology for multi- disciplinary, independent faculty to establish new research programs have also been made available. We propose to utilize the Center to facilitate on-going Digestive Diseases research, promote translational research between basic and clinical areas, develop new projects, nurture new investigators, and provide GI educational activities. Support is requested for Basic Science Cores (Morphology, Cell and Molecular Biology, Gastrointestinal Immunology, Integrative Biology) and one Clinical Core (Study Design and Specimen Collection). Pilot/Feasibility and Enrichment Programs to support innovative Programs to support innovative ideas and new investigators in Digestive Disease research and foster collaboration are a key part of our Center. The Center draws together a multi-disciplinary group of investigators, including basic scientists with proven track records of success, and well- coordinated clinical programs dealing with pediatric and adult GI patients. Center leaders are senior scientists-administrators experienced in directing interactive, multi-disciplinary programs. A large, multi-ethnic population of infants and adults with Digestive Diseases emphasizes the need and the opportunities for this Center. Various groups involved in GI research and education in the Gulf Coast Area of Texas have indicated a willingness to work with the Center. The elements are in place for a NIDDK-funded DDRCC to promote coordinated Digestive Disease activities in the area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056338-03
Application #
6635190
Study Section
Special Emphasis Panel (ZDK1-GRB-4 (M1))
Program Officer
Podskalny, Judith M,
Project Start
2001-04-15
Project End
2006-02-28
Budget Start
2003-03-01
Budget End
2004-02-29
Support Year
3
Fiscal Year
2003
Total Cost
$900,000
Indirect Cost
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Hernaez, Ruben; Kanwal, Fasiha; El-Serag, Hashem B (2018) Hepatocellular carcinoma screening is associated with survival benefit in silico but needs confirmation in an in vivo analysis. Hepatology 68:7-9
Kramer, J R; Puenpatom, A; Erickson, K F et al. (2018) Real-world effectiveness of elbasvir/grazoprevir In HCV-infected patients in the US veterans affairs healthcare system. J Viral Hepat 25:1270-1279
Stewart, Christopher J; Auchtung, Thomas A; Ajami, Nadim J et al. (2018) Effects of tobacco smoke and electronic cigarette vapor exposure on the oral and gut microbiota in humans: a pilot study. PeerJ 6:e4693
Ihekweazu, Faith D; Versalovic, James (2018) Development of the Pediatric Gut Microbiome: Impact on Health and Disease. Am J Med Sci 356:413-423
Chiang, Yun-Chen; Park, In-Young; Terzo, Esteban A et al. (2018) SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. Cancer Res 78:3135-3146
Hu, Liya; Sankaran, Banumathi; Laucirica, Daniel R et al. (2018) Glycan recognition in globally dominant human rotaviruses. Nat Commun 9:2631
Fekry, Baharan; Ribas-Latre, Aleix; Baumgartner, Corrine et al. (2018) Incompatibility of the circadian protein BMAL1 and HNF4? in hepatocellular carcinoma. Nat Commun 9:4349
Robayo-Torres, Claudia C; Diaz-Sotomayor, Marisela; Hamaker, Bruce R et al. (2018) 13C-Labeled-Starch Breath Test in Congenital Sucrase-isomaltase Deficiency. J Pediatr Gastroenterol Nutr 66 Suppl 3:S61-S64
Menon, Renuka T; Shrestha, Amrit Kumar; Barrios, Roberto et al. (2018) Hyperoxia Disrupts Extracellular Signal-Regulated Kinases 1/2-Induced Angiogenesis in the Developing Lungs. Int J Mol Sci 19:
Liu, Yanhong; O'Brien, Jacqueline L; Ajami, Nadim J et al. (2018) Lung tissue microbial profile in lung cancer is distinct from emphysema. Am J Cancer Res 8:1775-1787

Showing the most recent 10 out of 1121 publications