The primary goal of the recently renamed Functional Genomics and Microbiome Core (Core C) is to enhance research programs in infection and injury states affecting the mammalian intestine and liver by providing genomics and metagenomics expertise and resources. In this Core, we utilize advanced technology in mammalian and microbial genomics to support ongoing and innovative research to prevent and cure digestive diseases. This Core enables investigators to posit research questions related to gene expression, functional genomics and molecular mechanisms by utilizing the tools of microarrays, deep nucleic acid sequencing (microbial and mammalian), nucleic acid amplification, protein profiling, and bioinformatics. PCR based analyses of gene expression and splicing, DNA mutation/SNP detection, and gene pathway analyses ofthe mammalian metagenome (microbe and man) will be fostered by this Core as a platform for gastrointestinal and hepatic systems biology. Our mission is to provide a full service resource from experimental design to consultations about specimen processing, robust data analysis pipelines, and biostatistical support. In summary, we have created a fully integrated genomic analysis platform for investigators studying digestive diseases.

Public Health Relevance

This Core provides help with complex molecular technologies such as gene expression profiling and genomic microarray analyses, complex protein bead assays, metagenomic sequencing and microbiome analyses needed by DDC members.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK056338-11
Application #
8474132
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O2))
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
11
Fiscal Year
2013
Total Cost
$195,625
Indirect Cost
$70,625
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Ha, Kyungsoo; Ma, Chengxian; Lin, Han et al. (2017) The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun 8:15751
Desai, Moreshwar S; Mathur, Bhoomika; Eblimit, Zeena et al. (2017) Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart. Hepatology 65:189-201
Mindikoglu, Ayse L; Pappas, Stephen C (2017) New Developments in Hepatorenal Syndrome. Clin Gastroenterol Hepatol :
Wei, Qiong; Lee, Jong Han; Wang, Hongying et al. (2017) Adiponectin is required for maintaining normal body temperature in a cold environment. BMC Physiol 17:8
Tanaka, Shingo; Nagashima, Hiroyuki; Cruz, Modesto et al. (2017) Interleukin-17C in Human Helicobacter pylori Gastritis. Infect Immun 85:
Lo, Yuan-Hung; Chung, Eunah; Li, Zhaohui et al. (2017) Transcriptional Regulation by ATOH1 and its Target SPDEF inĀ theĀ Intestine. Cell Mol Gastroenterol Hepatol 3:51-71
Hollier, John M; Czyzewski, Danita I; Self, Mariella M et al. (2017) Pediatric Irritable Bowel Syndrome Patient and Parental Characteristics Differ by Care Management Type. J Pediatr Gastroenterol Nutr 64:391-395
Martin, Camilia R; Stoll, Barbara; Cluette-Brown, Joanne et al. (2017) Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA. Nutr Res 39:51-60
Vernetti, Lawrence; Gough, Albert; Baetz, Nicholas et al. (2017) Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep 7:42296
Figueroa, Elizabeth; Bugga, Pallavi; Asthana, Vishwaratn et al. (2017) A mechanistic investigation exploring the differential transfection efficiencies between the easy-to-transfect SK-BR3 and difficult-to-transfect CT26 cell lines. J Nanobiotechnology 15:36

Showing the most recent 10 out of 1007 publications