Adipose tissue function is central to overall metabolism. In addition to its energy storage role, adipose tissue secretes bioactive factors (i.e. adipokines) that contribute to regulating food intake, energy expenditure and normal functioning of key organs such as the vasculature, muscle and liver. Excessive expansion of adipose tissue, as occurs in obesity, is associated with cardiovascular abnormalities and systemic inflammation which ultimately may promote development of cardiovascular disease, diabetes and cancer. Adipose tissue expansion involves processes that include adipocyte hypertrophy, adipogenesis (pre-adipocyte differentiation), angiogenesis (new blood vessel formation) and extracellular matrix remodeling. There is growing interest in targeting these processes as a potentially efficient way to limit adipose tissue mass and obesity. In addition, understanding the molecular mechanisms that mediate lipid storage and the nutritional effects on adipose tissue metabolism are important in the pathophysiology of obesity. The Adipocyte Biology and Molecular Nutrition (ABMN) Core was established in 2006 and has since played a central role in facilitating molecular research related to nutrition and obesity by NORC investigators. The core provides NORC researchers, especially young investigators, access to specific equipment and expertise that are difficult to assemble by individual investigators and that can present a barrier to those new to this field. The state-of-the-art research infrastructure and training available through the ABMN Core facilitate and enhance nutrition/obesity related research and maximize resource use for NORC investigators, particularly young investigators who are establishing independent research programs. The core helps clinical investigators who are interested in the mechanisms underlying the pathophysiology associated with obesity in conducting molecular studies of biopsy samples obtained from metabolically phenotyped subjects. The ABMN core also creates opportunities for interactions and collaborations that often lead to initiation of new multidiscipiinary projects and help recruit basic and clinical investigators to nutrition/obesity related research (see publication record).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK056341-11
Application #
8132696
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Project Start
2011-04-01
Project End
2016-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
11
Fiscal Year
2011
Total Cost
$115,134
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Racette, Susan B; Rochon, James; Uhrich, Mary L et al. (2017) Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Med Sci Sports Exerc 49:2240-2249
Semenkovich, Clay F (2017) We Know More Than We Can Tell About Diabetes and Vascular Disease: The 2016 Edwin Bierman Award Lecture. Diabetes 66:1735-1741
Cade, W Todd; Reeds, Dominic N; Peterson, Linda R et al. (2017) Endurance Exercise Training in Young Adults with Barth Syndrome: A Pilot Study. JIMD Rep 32:15-24
Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2017) Sleeve gastrectomy surgery: When 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis :
Ovod, Vitaliy; Ramsey, Kara N; Mawuenyega, Kwasi G et al. (2017) Amyloid ? concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis. Alzheimers Dement 13:841-849
Lin, Xiaobo; Racette, Susan B; Ma, Lina et al. (2017) Ezetimibe Increases Endogenous Cholesterol Excretion in Humans. Arterioscler Thromb Vasc Biol 37:990-996
Lawson, H A; Zayed, M; Wayhart, J P et al. (2017) Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans. Int J Obes (Lond) 41:631-638
Weiss, Edward P; Jordan, Richard C; Frese, Ethel M et al. (2017) Effects of Weight Loss on Lean Mass, Strength, Bone, and Aerobic Capacity. Med Sci Sports Exerc 49:206-217
Biltz, Nicole K; Meyer, Gretchen A (2017) A novel method for the quantification of fatty infiltration in skeletal muscle. Skelet Muscle 7:1
Weiss, Edward P; Reeds, Dominic N; Ezekiel, Uthayashanker R et al. (2017) Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity. Endocrine 55:153-164

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