The Washington University NORC research base is diverse and multidisciplinary, collaborative and productive. Research activities of NORC investigators span across many disciplines and include basic cellular and molecular research, animal model studies, clinical investigation and community science. The NORC research focus is: (1) Obesity: Pathophysiology, Complications and Therapeutics;(2) Nutrient Metabolism in Health and Disease;and (3) Growth, Development, and Aging. The NORC research base has increased from 78 members at the beginning of the current funding cycle in 2006 to 115 members (97 Full Members and 18 Associate Members) now in 2010. The growth in NORC investigators represents adding 54 new faculty during the current funding cycle (2006-2010) because of an increase in funded Washington University faculty who developed research interests along the themes of the NORC and by the recruitment of new faculty with career interests in nutrition and obesity. The enhanced profile of nutrition and obesity within the medical center produced by the NORC, the services and intellectual expertise of the Core laboratories, the P&F Program, and the influence of NORC leadership throughout the medical center have been important factors in attracting investigators from different disciplines and departments to conduct nutrition/obesity research and helped in the recruitment of new faculty from other institutions. Most of the new NORC members are conducting obesity-related research (prevention &therapy, pathophysiology and complications). Therefore, although the major research themes proposed for the next funding cycle are similar to those we have now, there has been a marked increase in the absolute and relative number of investigators who are focused on some aspect of obesity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056341-12
Application #
8249817
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Program Officer
Evans, Mary
Project Start
1999-09-30
Project End
2016-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
12
Fiscal Year
2012
Total Cost
$1,109,866
Indirect Cost
$379,691
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Lucey, Brendan P; Mawuenyega, Kwasi G; Patterson, Bruce W et al. (2016) Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System. JAMA Neurol :
Piggott, Damani A; Erlandson, Kristine M; Yarasheski, Kevin E (2016) Frailty in HIV: Epidemiology, Biology, Measurement, Interventions, and Research Needs. Curr HIV/AIDS Rep 13:340-348
Magkos, Faidon; Fraterrigo, Gemma; Yoshino, Jun et al. (2016) Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity. Cell Metab 23:591-601
G Clifton, Rebecca; Evans, Mary; Cahill, Alison G et al. (2016) Design of lifestyle intervention trials to prevent excessive gestational weight gain in women with overweight or obesity. Obesity (Silver Spring) 24:305-13
Saben, Jessica L; Boudoures, Anna L; Asghar, Zeenat et al. (2016) Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations. Cell Rep 16:1-8
Armamento-Villareal, R; Aguirre, L E; Qualls, C et al. (2016) Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men. J Nutr Health Aging 20:334-40
Martínez-Montañés, Fernando; Lone, Museer A; Hsu, Fong-Fu et al. (2016) Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether. J Lipid Res 57:2040-2050
Fabbrini, Elisa; Tiemann Luecking, Courtney; Love-Gregory, Latisha et al. (2016) Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity. Gastroenterology 150:79-81.e2
Chondronikola, M; Harris, L L S; Klein, S (2016) Bariatric surgery and type 2 diabetes: are there weight loss-independent therapeutic effects of upper gastrointestinal bypass? J Intern Med 280:476-486
Yoshino, Jun; Smith, Gordon I; Kelly, Shannon C et al. (2016) Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults. Physiol Rep 4:

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