The Washington University NORC research base is diverse and multidisciplinary, collaborative and productive. Research activities of NORC investigators span across many disciplines and include basic cellular and molecular research, animal model studies, clinical investigation and community science. The NORC research focus is: (1) Obesity: Pathophysiology, Complications and Therapeutics;(2) Nutrient Metabolism in Health and Disease;and (3) Growth, Development, and Aging. The NORC research base has increased from 78 members at the beginning of the current funding cycle in 2006 to 115 members (97 Full Members and 18 Associate Members) now in 2010. The growth in NORC investigators represents adding 54 new faculty during the current funding cycle (2006-2010) because of an increase in funded Washington University faculty who developed research interests along the themes of the NORC and by the recruitment of new faculty with career interests in nutrition and obesity. The enhanced profile of nutrition and obesity within the medical center produced by the NORC, the services and intellectual expertise of the Core laboratories, the P&F Program, and the influence of NORC leadership throughout the medical center have been important factors in attracting investigators from different disciplines and departments to conduct nutrition/obesity research and helped in the recruitment of new faculty from other institutions. Most of the new NORC members are conducting obesity-related research (prevention &therapy, pathophysiology and complications). Therefore, although the major research themes proposed for the next funding cycle are similar to those we have now, there has been a marked increase in the absolute and relative number of investigators who are focused on some aspect of obesity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056341-13
Application #
8450895
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Program Officer
Evans, Mary
Project Start
1999-09-30
Project End
2016-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
13
Fiscal Year
2013
Total Cost
$1,044,854
Indirect Cost
$357,450
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Sun, Shishuo; Tan, Pengcheng; Huang, Xiaoheng et al. (2018) Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes. J Biol Chem 293:2383-2394
Acevedo, María Belén; Ferrando, Ramiro; Patterson, Bruce W et al. (2018) Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis :
Frolova, Antonina I; Wang, Judy J; Conner, Shayna N et al. (2018) Spontaneous Labor Onset and Outcomes in Obese Women at Term. Am J Perinatol 35:59-64
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Turk, John; White, Tayleur D; Nelson, Alexander J et al. (2018) iPLA2? and its role in male fertility, neurological disorders, metabolic disorders, and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids :
Shibao, Cyndya A; Celedonio, Jorge E; Tamboli, Robyn et al. (2018) CD36 Modulates Fasting and Preabsorptive Hormone and Bile Acid Levels. J Clin Endocrinol Metab 103:1856-1866
Mukherjee, Sumit; Xu, Wei; Hsu, Fong-Fu et al. (2018) Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major. Mol Microbiol :
Goldner, Nicholas K; Bulow, Christopher; Cho, Kevin et al. (2018) Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum. mSphere 3:
Higgins, Cassandra B; Zhang, Yiming; Mayer, Allyson L et al. (2018) Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPAR?. JCI Insight 3:
Wildburger, Norelle C; Gyngard, Frank; Guillermier, Christelle et al. (2018) Amyloid-? Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity. Front Neurol 9:169

Showing the most recent 10 out of 1334 publications