The Washington University NORC research base is diverse and multidisciplinary, collaborative and productive. Research activities of NORC investigators span across many disciplines and include basic cellular and molecular research, animal model studies, clinical investigation and community science. The NORC research focus is: (1) Obesity: Pathophysiology, Complications and Therapeutics;(2) Nutrient Metabolism in Health and Disease;and (3) Growth, Development, and Aging. The NORC research base has increased from 78 members at the beginning of the current funding cycle in 2006 to 115 members (97 Full Members and 18 Associate Members) now in 2010. The growth in NORC investigators represents adding 54 new faculty during the current funding cycle (2006-2010) because of an increase in funded Washington University faculty who developed research interests along the themes of the NORC and by the recruitment of new faculty with career interests in nutrition and obesity. The enhanced profile of nutrition and obesity within the medical center produced by the NORC, the services and intellectual expertise of the Core laboratories, the P&F Program, and the influence of NORC leadership throughout the medical center have been important factors in attracting investigators from different disciplines and departments to conduct nutrition/obesity research and helped in the recruitment of new faculty from other institutions. Most of the new NORC members are conducting obesity-related research (prevention &therapy, pathophysiology and complications). Therefore, although the major research themes proposed for the next funding cycle are similar to those we have now, there has been a marked increase in the absolute and relative number of investigators who are focused on some aspect of obesity.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Program Officer
Evans, Mary
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
Zip Code
Elbert, Donald L; Patterson, Bruce W; Bateman, Randall J (2015) Analysis of a compartmental model of amyloid beta production, irreversible loss and exchange in humans. Math Biosci 261:48-61
Magkos, Faidon; Smith, Gordon I; Reeds, Dominic N et al. (2014) One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men. Obesity (Silver Spring) 22:435-40
Clugston, Robin D; Yuen, Jason J; Hu, Yunying et al. (2014) CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis. J Lipid Res 55:239-46
Hsu, Fong-Fu; Lodhi, Irfan J; Turk, John et al. (2014) Structural distinction of diacyl-, alkylacyl, and alk-1-enylacyl glycerophosphocholines as [M - 15]? ions by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom 25:1412-20
Wardlaw, Sharon L; Burant, Charles F; Klein, Samuel et al. (2014) Continuous 24-hour leptin, proopiomelanocortin, and amino acid measurements in human cerebrospinal fluid: correlations with plasma leptin, soluble leptin receptor, and amino acid levels. J Clin Endocrinol Metab 99:2540-8
Pepino, Marta Yanina; Bradley, David; Eagon, J Christopher et al. (2014) Changes in taste perception and eating behavior after bariatric surgery-induced weight loss in women. Obesity (Silver Spring) 22:E13-20
Lei, Xiaoyong; Bone, Robert N; Ali, Tomader et al. (2014) Evidence of contribution of iPLA2?-mediated events during islet ?-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2? in T1D development. Endocrinology 155:3352-64
Rizza, Wanda; Veronese, Nicola; Fontana, Luigi (2014) What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Res Rev 13:38-45
Chowdhury, Sara; Reeds, Dominic N; Crimmins, Dan L et al. (2014) Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes. Am J Physiol Gastrointest Liver Physiol 306:G301-9
Wei, Xiaochao; Song, Haowei; Semenkovich, Clay F (2014) Insulin-regulated protein palmitoylation impacts endothelial cell function. Arterioscler Thromb Vasc Biol 34:346-54

Showing the most recent 10 out of 846 publications