I. Evolution of the NORC Research Base. The strength of the UNC NORC research base is that it is both large enough and strong enough to effectively span a variety of disciplines within nutritional sciences and obesity related research. From population-based to molecular research, our Center gains from the integration of these diverse perspectives and approaches. Our faculty members are international leaders in nutrition and obesity research, publishing in top journals and directing major nutrition/obesity studies. At the population level, our investigators lead some of the largest NIH-funded nutrition-focused studies including the Long Island Breast Cancer Study (18,000 women), Atherosclerosis Risk in Communities (ARIC: 15,792 men and women), Trial of Activity in Adolescent Girls (TAAG: 8,728 women), WAY to Health Study (1,200 employees at 12 community colleges), The Hispanic Cohort Health Study (16,000 men and women) and the Carolina Head and Neck Cancer Study (CHANCE: 1,400 men and women), to name a few. Our investigators are at the leading edge of studying the global nutrition transition, with major longitudinal studies in the United States, China and the Philippines. At the clinical nutrition research level, we are leaders in the developing field of nutrigenomics as it influences dietary nutrient requirements (including organizing workshops for the American Society of Nutrition at the 2010 and 2011 Experimental Biology annual meetings). Our members have generated critical information needed for the Dietary Reference Intakes (DRI) development process, and several of our members served on the Institute of Medicine panels that developed those DRIs. At the molecular level, our investigators have made fundamental contributions to the understanding of the genes that regulate activity, lipid and choline metabolism, the effects of obesity on immune responses to viruses, and the mechanisms whereby antioxidants and selenium modulate viral mutation and pathogenesis. We are also leaders in identifying, in both mice and humans, gene loci that regulate adipose distribution, insulin resistance, and glucose metabolism. These examples are only a small portion of the large number of contributions made by the NORC research base. The NORC leadership has worked hard to build a strong and diverse research base. We measure our success as a Center by the strength of our membership, the investment in nutrition and obesity research, and the quantity and quality of publications generated by our members.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-2 (J2))
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Evans, Mary
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University of North Carolina Chapel Hill
Schools of Public Health
Chapel Hill
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Rummo, Pasquale E; Albrecht, Sandra S; Gordon-Larsen, Penny (2015) Field validation of food outlet databases: the Latino food environment in North Carolina, USA. Public Health Nutr 18:977-82
Hiller, Sylvia; DeKroon, Robert; Xu, Longquan et al. (2014) ?-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice. Free Radic Biol Med 71:362-7
Allicock, Marlyn; Carr, Carol; Johnson, La-Shell et al. (2014) Implementing a one-on-one peer support program for cancer survivors using a motivational interviewing approach: results and lessons learned. J Cancer Educ 29:91-8
May, Philip A; Hamrick, Kari J; Corbin, Karen D et al. (2014) Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa. Reprod Toxicol 46:31-9
Thompson, Amanda L; Houck, Kelly M; Adair, Linda et al. (2014) Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults. Am J Hum Biol 26:18-28
Niu, Jingjing; Seo, Dong-Chul (2014) Central obesity and hypertension in Chinese adults: a 12-year longitudinal examination. Prev Med 62:113-8
Richardson, Andrea S; Meyer, Katie A; Howard, Annie Green et al. (2014) Neighborhood socioeconomic status and food environment: a 20-year longitudinal latent class analysis among CARDIA participants. Health Place 30:145-53
Crowley, James J; Kim, Yunjung; Lenarcic, Alan B et al. (2014) Genetics of adverse reactions to haloperidol in a mouse diallel: a drug-placebo experiment and Bayesian causal analysis. Genetics 196:321-47
Wen, Wanqing; Zheng, Wei; Okada, Yukinori et al. (2014) Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet 23:5492-504
Miller, Carolyn A; Corbin, Karen D; da Costa, Kerry-Ann et al. (2014) Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Am J Clin Nutr 100:778-86

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