I. Evolution of the NORC Research Base. The strength of the UNC NORC research base is that it is both large enough and strong enough to effectively span a variety of disciplines within nutritional sciences and obesity related research. From population-based to molecular research, our Center gains from the integration of these diverse perspectives and approaches. Our faculty members are international leaders in nutrition and obesity research, publishing in top journals and directing major nutrition/obesity studies. At the population level, our investigators lead some of the largest NIH-funded nutrition-focused studies including the Long Island Breast Cancer Study (18,000 women), Atherosclerosis Risk in Communities (ARIC: 15,792 men and women), Trial of Activity in Adolescent Girls (TAAG: 8,728 women), WAY to Health Study (1,200 employees at 12 community colleges), The Hispanic Cohort Health Study (16,000 men and women) and the Carolina Head and Neck Cancer Study (CHANCE: 1,400 men and women), to name a few. Our investigators are at the leading edge of studying the global nutrition transition, with major longitudinal studies in the United States, China and the Philippines. At the clinical nutrition research level, we are leaders in the developing field of nutrigenomics as it influences dietary nutrient requirements (including organizing workshops for the American Society of Nutrition at the 2010 and 2011 Experimental Biology annual meetings). Our members have generated critical information needed for the Dietary Reference Intakes (DRI) development process, and several of our members served on the Institute of Medicine panels that developed those DRIs. At the molecular level, our investigators have made fundamental contributions to the understanding of the genes that regulate activity, lipid and choline metabolism, the effects of obesity on immune responses to viruses, and the mechanisms whereby antioxidants and selenium modulate viral mutation and pathogenesis. We are also leaders in identifying, in both mice and humans, gene loci that regulate adipose distribution, insulin resistance, and glucose metabolism. These examples are only a small portion of the large number of contributions made by the NORC research base. The NORC leadership has worked hard to build a strong and diverse research base. We measure our success as a Center by the strength of our membership, the investment in nutrition and obesity research, and the quantity and quality of publications generated by our members.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056350-12
Application #
8251132
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Program Officer
Evans, Mary
Project Start
1999-09-30
Project End
2016-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
12
Fiscal Year
2012
Total Cost
$1,105,125
Indirect Cost
$336,073
Name
University of North Carolina Chapel Hill
Department
Nutrition
Type
Schools of Public Health
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Rummo, Pasquale E; Guilkey, David K; Ng, Shu Wen et al. (2017) Does unmeasured confounding influence associations between the retail food environment and body mass index over time? The Coronary Artery Risk Development in Young Adults (CARDIA) study. Int J Epidemiol 46:1456-1464
Zhang, Le; Burant, Alex; McCallister, Andrew et al. (2017) Accurate MR thermometry by hyperpolarized 129 Xe. Magn Reson Med 78:1070-1079
Tian, Xu; Ding, Caicui; Shen, Chong et al. (2017) Does Parental Migration Have Negative Impact on the Growth of Left-Behind Children?-New Evidence from Longitudinal Data in Rural China. Int J Environ Res Public Health 14:
Gerstner, Gena R; Ryan, Eric D; Kleinberg, Craig R et al. (2017) Consistency of a mobile body composition trailer: a novel portable laboratory assessment? Clin Physiol Funct Imaging 37:544-547
Dearth-Wesley, Tracy; Howard, Annie Green; Wang, Huijun et al. (2017) Trends in domain-specific physical activity and sedentary behaviors among Chinese school children, 2004-2011. Int J Behav Nutr Phys Act 14:141
Shapiro, Allison L B; Ringham, Brandy M; Glueck, Deborah H et al. (2017) Infant Adiposity is Independently Associated with a Maternal High Fat Diet but not Related to Niacin Intake: The Healthy Start Study. Matern Child Health J 21:1662-1668
Styner, Maya; Pagnotti, Gabriel M; McGrath, Cody et al. (2017) Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice. J Bone Miner Res 32:1692-1702
Rummo, Pasquale E; Guilkey, David K; Ng, Shu Wen et al. (2017) Beyond Supermarkets: Food Outlet Location Selection in Four U.S. Cities Over Time. Am J Prev Med 52:300-310
Clauss, Sebastian; Scherr, Johannes; Hanley, Alan et al. (2017) Impact of polyphenols on physiological stress and cardiac burden in marathon runners - results from a substudy of the BeMaGIC study. Appl Physiol Nutr Metab 42:523-528
Corsino, Leonor; Sotres-Alvarez, Daniela; Butera, Nicole M et al. (2017) Association of the DASH dietary pattern with insulin resistance and diabetes in US Hispanic/Latino adults: results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). BMJ Open Diabetes Res Care 5:e000402

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