Statement of work The Broad Institute will support the work of BADERC investigators through engagement of the following Broad Platforms: Metabolite Profiling, Proteomics, RNAi and Genetic Analysis. We propose two modes in which BADERC investigators can utilize this support: First is through the pre-existing Pilot and Feasibility process. We envision that a number of these P&F proposals will aim to incorporate Broad platform capabilities in their proposals (for example, a project that performs metabolic profiling and / or RNAi screening capabilities, or that utilizes SNP genotyping in a human genetic aims with the Genetic Analysis Platform). The Project Manager (Ms. Burtt) and PI (Altshuler) will help investigators identify and engage these opportunities, to interact with platform staff to assess feasibility and details of experimental design, and to write proposals utilizing these platforms. If these P&F proposals are judged meritorious and selected for funding (by the existing BADERC mechanism), then the costs incurred by the Broad platforms would be supported by the budgeted funds. The program manager would then facilitate the execution of the approved project activities. Second, there are a number of platform capabilities that will be available to BADERC investigators as needed based on their existing research. Examples might include SNP genotyping for an ongoing project that tests whether a novel candidate gene contributes to a diabetes-related phenotype in humans, or creation of new RNAi reagents to perform knock-down assays in a cellular diabetes model. The Broad subcontract will support access to such Broad platform capabilities by each BADERC investigator (up to a pre-specified limit per investigator, not to exceed the total budgeted). As above, the project manager would serve as a key liaison between BADERC investigators and Broad Platforms, helping identify which capabilities matched each funding mechanism, guiding investigators to the relevant staff, and facilitating successful execution of each approved activity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK057521-15
Application #
8639532
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
15
Fiscal Year
2014
Total Cost
$126,980
Indirect Cost
$20,223
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Williams, Erika K; Chang, Rui B; Strochlic, David E et al. (2016) Sensory Neurons that Detect Stretch and Nutrients in the Digestive System. Cell 166:209-21
Inoue, Yoshitaka; Yu, Yong-Ming; Kurihara, Tomohiro et al. (2016) Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. Crit Care Med 44:e241-52
Burgess, Christian R; Ramesh, Rohan N; Sugden, Arthur U et al. (2016) Hunger-Dependent Enhancement of Food Cue Responses in Mouse Postrhinal Cortex and Lateral Amygdala. Neuron 91:1154-69
Shahid, Mohd; Javed, Ammar A; Chandra, David et al. (2016) IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity. Sci Rep 6:24135
Bonner-Weir, Susan; Aguayo-Mazzucato, Cristina; Weir, Gordon C (2016) Dynamic development of the pancreas from birth to adulthood. Ups J Med Sci 121:155-8
Crowley, Nicole A; Bloodgood, Daniel W; Hardaway, J Andrew et al. (2016) Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep 14:2774-83
Noonan, Haley R; Metelo, Ana M; Kamei, Caramai N et al. (2016) Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma. Dis Model Mech 9:873-84
Trepiccione, Francesco; Gerber, Simon D; Grahammer, Florian et al. (2016) Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System. J Am Soc Nephrol 27:3320-3330
Roy, Jeremy; Kim, Bongki; Hill, Eric et al. (2016) Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun 7:10666
Moraes-Vieira, Pedro M; Saghatelian, Alan; Kahn, Barbara B (2016) GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. Diabetes 65:1808-15

Showing the most recent 10 out of 300 publications