This application is for continued support of the Vanderbilt Digestive Disease Research Center (VDDRC) which is focused on developing a deeper understanding of gastrointestinal physiology and pathophysiologic responses to injury and inflammation in order to reveal new mechanisms of disease and novel therapeutic targets. The VDDRC is multidisciplinary, including faculty in 14 different academic departments with 119 investigators (65 full members and 48 associate members).
The Aims of the VDDRC are aligned with the goals of Vanderbilt University: 1) to promote digestive disease-related research in an integrative, collaborative and multidisciplinary manner;2) to develop and implement programs for attracting, training, and retaining young investigators in digestive disease-related research;3) to enhance the basic, translational, and clinical research capabilities of VDDRC members;4) to facilitate the transfer of basic research discoveries to improvements in prevention and/or clinical care;and 5) to attract investigators not involved indigestive disease-related research to pursue these lines of investigation. Investigative member interests fall into four broad areas of study: 1) Growth, proliferation, and apoptosis;2) Epithelial integrity;3) Gastrointestinal physiology, obesity, and metabolism;and 4) Gastrointestinal development and function. The VDDRC contains five core research laboratories to support the members: 1) Flow Cytometry Core, 2) Preclinical Models of Digestive Diseases Core, 3) Cell Imaging Core, 4) Bioanalytical (Mass Spectrometry) and Proteomics Core, and 5) Murine Gl Surgical Modeling Core. These cores are integrated into our Center to provide investigators working on digestive disease-related research with the latest advances in technology and to aid in experimental design and interpretation of results. Based on investigator demand, in this competing renewal application, we have expanded our core services by adding 1) non-invasive molecular imaging to the original Cellular and Animal Modeling Core to create a Preclinical Models of Digestive Diseases Core, and 2) a Murine Gl Surgical Modeling Core. The VDDRC supports a Pilot/Feasibility Program including a university-supported translational project, a dual-funded VDDRC-Clinical and Translational Science Award (CTSA) clinical project, and a Young Investigator Award Program to foster participation of beginning and seasoned investigators in research related to digestive diseases. The Administrative Core also contains Biostatistics and Enrichment Programs and oversees the financial management and operation of the VDDRC.
|Engevik, Amy C; Kaji, Izumi; Engevik, Melinda A et al. (2018) Loss of MYO5B Leads to Reductions in Na+ Absorption With Maintenance of CFTR-Dependent Cl- Secretion in Enterocytes. Gastroenterology 155:1883-1897.e10|
|Tafreshi, Mona; Guan, Jyeswei; Gorrell, Rebecca J et al. (2018) Helicobacter pylori Type IV Secretion System and Its Adhesin Subunit, CagL, Mediate Potent Inflammatory Responses in Primary Human Endothelial Cells. Front Cell Infect Microbiol 8:22|
|Rogers, Meredith C; Lamens, Kristina D; Shafagati, Nazly et al. (2018) CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses. J Immunol 201:1253-1266|
|Lowry, Mary Allyson; Vaezi, Michael F; Correa, Hernan et al. (2018) Mucosal Impedance Measurements Differentiate Pediatric Patients With Active Versus Inactive Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr 67:198-203|
|Pollins, Alonda C; Boyer, Richard B; Nussenbaum, Marlieke et al. (2018) Comparing Processed Nerve Allografts and Assessing Their Capacity to Retain and Release Nerve Growth Factor. Ann Plast Surg 81:198-202|
|Hebron, Katie E; Li, Elizabeth Y; Arnold Egloff, Shanna A et al. (2018) Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis. Sci Rep 8:3208|
|Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:|
|Ruiz, Rachel M; Sommer, Evan C; Tracy, Dustin et al. (2018) Novel patterns of physical activity in a large sample of preschool-aged children. BMC Public Health 18:242|
|Bolus, W Reid; Peterson, Kristin R; Hubler, Merla J et al. (2018) Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab 8:86-95|
|Loh, John T; Beckett, Amber C; Scholz, Matthew B et al. (2018) High-Salt Conditions Alter Transcription of Helicobacter pylori Genes Encoding Outer Membrane Proteins. Infect Immun 86:|
Showing the most recent 10 out of 1365 publications