This application is for continued support of the Vanderbilt Digestive Disease Research Center (VDDRC) which is focused on developing a deeper understanding of gastrointestinal physiology and pathophysiologic responses to injury and inflammation in order to reveal new mechanisms of disease and novel therapeutic targets. The VDDRC is multidisciplinary, including faculty in 14 different academic departments with 119 investigators (65 full members and 48 associate members).
The Aims of the VDDRC are aligned with the goals of Vanderbilt University: 1) to promote digestive disease-related research in an integrative, collaborative and multidisciplinary manner;2) to develop and implement programs for attracting, training, and retaining young investigators in digestive disease-related research;3) to enhance the basic, translational, and clinical research capabilities of VDDRC members;4) to facilitate the transfer of basic research discoveries to improvements in prevention and/or clinical care;and 5) to attract investigators not involved indigestive disease-related research to pursue these lines of investigation. Investigative member interests fall into four broad areas of study: 1) Growth, proliferation, and apoptosis;2) Epithelial integrity;3) Gastrointestinal physiology, obesity, and metabolism;and 4) Gastrointestinal development and function. The VDDRC contains five core research laboratories to support the members: 1) Flow Cytometry Core, 2) Preclinical Models of Digestive Diseases Core, 3) Cell Imaging Core, 4) Bioanalytical (Mass Spectrometry) and Proteomics Core, and 5) Murine Gl Surgical Modeling Core. These cores are integrated into our Center to provide investigators working on digestive disease-related research with the latest advances in technology and to aid in experimental design and interpretation of results. Based on investigator demand, in this competing renewal application, we have expanded our core services by adding 1) non-invasive molecular imaging to the original Cellular and Animal Modeling Core to create a Preclinical Models of Digestive Diseases Core, and 2) a Murine Gl Surgical Modeling Core. The VDDRC supports a Pilot/Feasibility Program including a university-supported translational project, a dual-funded VDDRC-Clinical and Translational Science Award (CTSA) clinical project, and a Young Investigator Award Program to foster participation of beginning and seasoned investigators in research related to digestive diseases. The Administrative Core also contains Biostatistics and Enrichment Programs and oversees the financial management and operation of the VDDRC.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Grey, Michael J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Chaturvedi, R; de Sablet, T; Asim, M et al. (2015) Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene 34:3429-40
Krakowiak, M S; Noto, J M; Piazuelo, M B et al. (2015) Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene 34:1865-71
Wei, Jinxiong; Noto, Jennifer M; Zaika, Elena et al. (2015) Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Gut 64:1040-8
Wroblewski, Lydia E; Piazuelo, M Blanca; Chaturvedi, Rupesh et al. (2015) Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut 64:720-30
Otero, Yolanda F; Lundblad, Tammy M; Ford, Eric A et al. (2014) Liver but not adipose tissue is responsive to the pattern of enteral feeding. Physiol Rep 2:e00250
Buckman, Laura B; Hasty, Alyssa H; Flaherty, David K et al. (2014) Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Brain Behav Immun 35:33-42
Belkhiri, Abbes; El-Rifai, Wael (2014) 5-Methylcytosine hydroxylation-mediated LINE-1 hypomethylation: a novel mechanism of proto-oncogenes activation in colorectal cancer? Gut 63:538-9
Horst, Sara; Shelby, Grace; Anderson, Julia et al. (2014) Predicting persistence of functional abdominal pain from childhood into young adulthood. Clin Gastroenterol Hepatol 12:2026-32
Smith, Stephen; Tripathi, Rati; Goodings, Charnise et al. (2014) LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. PLoS One 9:e85883
Radin, Jana N; Gonzalez-Rivera, Christian; Frick-Cheng, Arwen E et al. (2014) Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Infect Immun 82:423-32

Showing the most recent 10 out of 620 publications