The overarching goal of the Administrative Core is to support the continuing development of the VDDRC Research Base and to ensure responsiveness of the Research Cores to the needs of VDDRC members and Pilot Project grant recipients. The administrative and scientific leadership of the VDDRC is provided by the Director, Richard Peek, and the Associate Directors, Naji Abumrad and Keith Wilson, and is augmented by the Scientific Advisory Board, composed of renowned internal and external investigators, and by the Executive Committee, which is comprised of the Director, Associate Directors, Core Directors, and Program Leaders. One administrative assistant provides the necessary support for day-to-day financial management and operations of the VDDRC. Vanderbilt University Medical Center provides exceptional institutional support and infrastructure to promote the continued growth of our center. The Administrative Core supports a Biostatistical Program directed by Dr. Tatsuki Koyama to assist pilot project applicants and recipients as well as our members in clinical and basic research study design, data analysis, and database management. An Enrichment Program co-directed by Dr. Abumrad, fosters new investigation in digestive diseases research by supporting prominent scientists to present research seminars at Vanderbilt, enhancing core utilization by addressing member research needs, and through an annual retreat. The seminar series and the retreat provide opportunities for communication and promote collaboration through scientific and technical interactions between members and Core Directors. The Enrichment Program also supports acquisition of new skills through the Enrichment Training (mini-sabbatical) Program. The Clinical Component of the VDDRC Is directed by Dr. Abumrad and provides clinical and translational platforms for VDDRC investigators to transition mechanistic studies into appropriate human populations. The Administrative Core oversees the Pilot and Feasibility Project Program, which has invested >$1.9M into investigator-initiated research since inception of the VDDRC and is directed by Dr. Wilson. This program is designed to attract new and seasoned investigators to pursue digestive diseases research in the four research areas of the VDDRC: 1) Growth, proliferation and apoptosis;2) Epithelial integrity;3), Gastrointestinal physiology, obesity and metabolism;and 4) Gastrointestinal development and function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK058404-13
Application #
8665895
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Means, Anna L; Freeman, Tanner J; Zhu, Jing et al. (2018) Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Cell Mol Gastroenterol Hepatol 6:257-276
Bloodworth, Melissa H; Rusznak, Mark; Pfister, Connor C et al. (2018) Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology. J Allergy Clin Immunol 142:683-687.e12
Weiss, Vivian L; Kiernan, Colleen; Wright, Jesse et al. (2018) Fine-Needle Aspiration-Based Grading of Pancreatic Neuroendocrine Neoplasms Using Ki-67: Is Accurate WHO Grading Possible on Cytologic Material? J Am Soc Cytopathol 7:154-459
Moon, Jiyun M; Aronoff, David M; Capra, John A et al. (2018) Examination of Signatures of Recent Positive Selection on Genes Involved in Human Sialic Acid Biology. G3 (Bethesda) 8:1315-1325
Feng, Yinnian; Reinherz, Ellis L; Lang, Matthew J (2018) ?? T Cell Receptor Mechanosensing Forces out Serial Engagement. Trends Immunol 39:596-609
Roberts, Jordan; Gonzalez, Raul S; Revetta, Frank et al. (2018) Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells. Histopathology 73:795-800
Lindsey, Amelia R I; Rice, Danny W; Bordenstein, Sarah R et al. (2018) Evolutionary Genetics of Cytoplasmic Incompatibility Genes cifA and cifB in Prophage WO of Wolbachia. Genome Biol Evol 10:434-451
Lopez, Christopher A; Skaar, Eric P (2018) The Impact of Dietary Transition Metals on Host-Bacterial Interactions. Cell Host Microbe 23:737-748
Cooke, Allison L; Morris, Jamie; Melchior, John T et al. (2018) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. J Lipid Res 59:1244-1255
Schulte, Michael L; Fu, Allie; Zhao, Ping et al. (2018) Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat Med 24:194-202

Showing the most recent 10 out of 1365 publications