The overarching goal of the Administrative Core is to support the continuing development of the VDDRC Research Base and to ensure responsiveness of the Research Cores to the needs of VDDRC members and Pilot Project grant recipients. The administrative and scientific leadership of the VDDRC is provided by the Director, Richard Peek, and the Associate Directors, Naji Abumrad and Keith Wilson, and is augmented by the Scientific Advisory Board, composed of renowned internal and external investigators, and by the Executive Committee, which is comprised of the Director, Associate Directors, Core Directors, and Program Leaders. One administrative assistant provides the necessary support for day-to-day financial management and operations of the VDDRC. Vanderbilt University Medical Center provides exceptional institutional support and infrastructure to promote the continued growth of our center. The Administrative Core supports a Biostatistical Program directed by Dr. Tatsuki Koyama to assist pilot project applicants and recipients as well as our members in clinical and basic research study design, data analysis, and database management. An Enrichment Program co-directed by Dr. Abumrad, fosters new investigation in digestive diseases research by supporting prominent scientists to present research seminars at Vanderbilt, enhancing core utilization by addressing member research needs, and through an annual retreat. The seminar series and the retreat provide opportunities for communication and promote collaboration through scientific and technical interactions between members and Core Directors. The Enrichment Program also supports acquisition of new skills through the Enrichment Training (mini-sabbatical) Program. The Clinical Component of the VDDRC Is directed by Dr. Abumrad and provides clinical and translational platforms for VDDRC investigators to transition mechanistic studies into appropriate human populations. The Administrative Core oversees the Pilot and Feasibility Project Program, which has invested >$1.9M into investigator-initiated research since inception of the VDDRC and is directed by Dr. Wilson. This program is designed to attract new and seasoned investigators to pursue digestive diseases research in the four research areas of the VDDRC: 1) Growth, proliferation and apoptosis;2) Epithelial integrity;3), Gastrointestinal physiology, obesity and metabolism;and 4) Gastrointestinal development and function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK058404-13
Application #
8665895
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Chen, Zheng; Hu, Tianling; Zhu, Shoumin et al. (2017) Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer. Oncotarget 8:54345-54356
Petersen, Christine P; Meyer, Anne R; De Salvo, Carlo et al. (2017) A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut :
Wang, Yang; Shi, Chanjuan; Eisenberg, Rosana et al. (2017) Differences in Microsatellite Instability Profiles between Endometrioid and Colorectal Cancers: A Potential Cause for False-Negative Results? J Mol Diagn 19:57-64
Noto, Jennifer M; Peek Jr, Richard M (2017) Helicobacter pylori Makes a Molecular Incision to Gain Epithelial Entry. Cell Host Microbe 22:434-436
Messaggio, Fanuel; Mendonsa, Alisha M; Castellanos, Jason et al. (2017) Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth. Oncotarget 8:85378-85391
Stephenson, Jason R; Wang, Xiaohan; Perfitt, Tyler L et al. (2017) A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J Neurosci 37:2216-2233
Nicholas, Katherine J; Flaherty, David K; Smith, Rita M et al. (2017) Chronic HIV-1 Infection Impairs Superantigen-Induced Activation of Peripheral CD4+CXCR5+PD-1+ Cells, With Relative Preservation of Recall Antigen-Specific Responses. J Acquir Immune Defic Syndr 74:72-80
Pilkinton, Mark A; Nicholas, Katherine J; Warren, Christian M et al. (2017) Greater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversion. Vaccine 35:329-336
LePage, Daniel P; Metcalf, Jason A; Bordenstein, Sarah R et al. (2017) Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature 543:243-247
Hardbower, D M; Coburn, L A; Asim, M et al. (2017) EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis. Oncogene 36:3807-3819

Showing the most recent 10 out of 1230 publications