The Overall mission of the UCSD/UCLA/Salk/Cedars Sinai DRC continues to center on fostering research in the prevention and treatment of diabetes and its complications to ultimately improve the lives of patients. For the past decade, our DRC has been unique in linking together the diabetes/metabolism research activities of two major universities within the UC system and two outstanding Institutes in Southern California. We believe this has been a novel, and a very successful effort. The DRC has fostered new collaborations and interactions between outstanding scientists within and across these institutions. Our research base is comprised of the following focus areas: Nuclear Receptors, Cell Signaling, Metabolism, Diabetes Complications, and Islet/Beta Cell Biology. Each of these areas has outstanding leaders who facilitate interactions and sharing of resources. The DRC has played an important role in promoting the careers of young scientists as they move on to the status of independent investigators by awarding pilot and feasibility grants. As an acknowledgement of our success in this effort, UCSD and. UCLA have agreed to provide over $100,000/year in additional unrestricted funds to augment our P&F program The DRC will continue to advance scientific and intellectual interactions by organizing and facilitating meetings, lectures, and mentoring efforts that are part of our enrichment core. We will further accelerate diabetes research at the four DRC Institutions by providing state-of-the-art services through five cutting edge cores: A) Transgenic and Knock-out Mouse Core, B) Metabolic and Molecular Physiology Core, C) Epigenetics and Genomics Core, D) Human Genetics Core, and E) Novel Target Discovery and Assay Development Core. All of our research cores have been updated with new services and latest technologies in the upcoming project period to reflect the many advances in this field as they relate to diabetes and metabolism research. Our cores are heavily used by our DRC faculty that have been exceptionally successful as can be judged by the numerous publications in high impact journals (665) and the substantial peer review grant support that they have accrued ($154,601,201). The current competitive renewal application includes many new scientific and technological advancements, including the incorporation of novel genomic, proteomic, and metabolomics services that are now available to our members. As future directions, we will continue to strive for seamless integration of research at all participating institutions to enhance technology and research capability within the DRC and to promote translational research activity and collaborations with the CTSI programs at each institution.

Public Health Relevance

The UCSD/UCLA DRC will enhance research into the etiology, pathophysiology, treatment, and prevention of diabetes mellitus and its complications through facilitation of scientific exchange, advancement of the outstanding scientific faculty comprising our research base, by providing access to novel biomedical research cores and promoting the careers of young scientists. This will ultimately improve the lives of patients with diabetes, who will benefit from the advancements the center will generate.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK063491-11
Application #
8435812
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Program Officer
Hyde, James F
Project Start
2002-12-01
Project End
2018-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
11
Fiscal Year
2013
Total Cost
$1,860,233
Indirect Cost
$400,303
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Mahajan, Anubha (see original citation for additional authors) (2018) Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet 50:559-571
Hajek, Catherine; Guo, Xiuqing; Yao, Jie et al. (2018) Coronary Heart Disease Genetic Risk Score Predicts Cardiovascular Disease Risk in Men, Not Women. Circ Genom Precis Med 11:e002324
Malik, Rainer (see original citation for additional authors) (2018) Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet 50:524-537
Kulminski, Alexander M; Huang, Jian; Loika, Yury et al. (2018) Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes. Aging (Albany NY) 10:492-514
Gao, Chuan; Tabb, Keri L; Dimitrov, Latchezar M et al. (2018) Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS). Sci Rep 8:5603
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Yuan, Xiaomei; Dong, Yi; Tsurushita, Naoya et al. (2018) CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms. JCI Insight 3:
Svensson, Kristoffer; Dent, Jess R; Tahvilian, Shahriar et al. (2018) Defining the contribution of skeletal muscle pyruvate dehydrogenase alpha 1 (Pdha1) to exercise performance and insulin action. Am J Physiol Endocrinol Metab :
Wang, Bo; Rong, Xin; Palladino, Elisa N D et al. (2018) Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell 22:206-220.e4
Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390

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