NIH-inifiated efforts to centralize expertise, instrumentafion, and facilifies to promote comprehensive evaluafion of genefically engineered mice, fissues and cells has improved our understanding of funcfional genomics and disease pathobiology. The Metabolic and Molecular Physiology Core (MMPC) provides investigators at UCLA, UCSD, Cedars-Sinai, and the Salk Institute with a series of state-of-the-art and costeffecfive molecular and physiological assays not readily available from nafional phenotyping centers. The MMPC is divided into four sub-cores: A) Insulin sensitivity and metabolism, B) Oxidative metabolism and mitochondrial biology, C) LIPID MAPS-lipidomics, and D) Inflammatory siganling, and each sub-core offers extensive training and consultafion on a variety of topics from experimental design to data interpretafion and integrafion. Specifically, the MMPC provides services to assess: movement, feeding behavior, indirect calorimetry, body composifion, glucose/insulin tolerance, insulin acfion, substrate metabolism and oxidative capacity, mitochondrial funcfion, circulafing and fissue lipids (lipidomics), circulafing hormones / adipokines / cytokines, and diabetes complicafions. The MMPC maintains a fissue bio-bank as well as a comprehensive database of standard protocols for a vast number of phenotyping techniques, and phenotypic outcomes for a wide variety of genefically engineered mice. The MMPC leadership includes top investigators from the fields of nuclear receptor biology, lipid metabolism, inflammafion, and adipocyte and skeletal muscle biology including: Peter Tontonoz, Andrea Hevener, Karen Reue, Rajendra Tangirala, Edward Dennis, Oswald Quehenberger. Strengths of the MMPC include the well-rounded and complementary expertise of its leadership and the excepfional track record of producfivity and high impact scientific publicafions. The collaborafive spirit ofthe MMPC team fosters a collegial environment and supports service well-coordinated with other DRC cores and institufional resources. The central goal ofthe MMPC is to advance the scientific capabilifies ofthe DRC membership in leading-edge metabolic analysis to improve overall research quality with enhanced translafiori of research ideas from cell, fissue and mouse to man.

Public Health Relevance

The UCSD-UCLA Metabolic and Molecular Physiology Core provides DRC investigators studying obesity, diabetes and diabetes-related complications access to novel, state-of-the-art in vivo and molecular analyses of metabolism, insulin action and inflammation, thus improving overall research quality and impact by enahncing translation of scientific ideas from cell, tissue and mouse to man.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-S)
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University of California San Diego
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Maggi, Maristella; Mittelman, Steven D; Parmentier, Jean Hugues et al. (2017) A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro. Sci Rep 7:14479
Kerr, Kathleen F; Avery, Christy L; Lin, Henry J et al. (2017) Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts. Heart Rhythm 14:1675-1684
Graff, Mariaelisa; Emery, Leslie S; Justice, Anne E et al. (2017) Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos. Lipids Health Dis 16:200
Wang, Jiexin; Rajbhandari, Prashant; Damianov, Andrey et al. (2017) RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. J Clin Invest 127:987-1004
Sobrin, Lucia; Chong, Yong He; Fan, Qiao et al. (2017) Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes 66:3130-3141
Ying, Wei; Wollam, Joshua; Ofrecio, Jachelle M et al. (2017) Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest 127:1019-1030
Xie, Huimin; Hoffmann, Hanne M; Iyer, Anita K et al. (2017) Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol 15:86
Gosselin, David; Skola, Dylan; Coufal, Nicole G et al. (2017) An environment-dependent transcriptional network specifies human microglia identity. Science 356:
Hernandez-Carretero, A; Weber, N; La Frano, M R et al. (2017) Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond) :
Rong, Xin; Wang, Bo; Palladino, Elisa Nd et al. (2017) ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest 127:3640-3651

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