NIH-inifiated efforts to centralize expertise, instrumentafion, and facilifies to promote comprehensive evaluafion of genefically engineered mice, fissues and cells has improved our understanding of funcfional genomics and disease pathobiology. The Metabolic and Molecular Physiology Core (MMPC) provides investigators at UCLA, UCSD, Cedars-Sinai, and the Salk Institute with a series of state-of-the-art and costeffecfive molecular and physiological assays not readily available from nafional phenotyping centers. The MMPC is divided into four sub-cores: A) Insulin sensitivity and metabolism, B) Oxidative metabolism and mitochondrial biology, C) LIPID MAPS-lipidomics, and D) Inflammatory siganling, and each sub-core offers extensive training and consultafion on a variety of topics from experimental design to data interpretafion and integrafion. Specifically, the MMPC provides services to assess: movement, feeding behavior, indirect calorimetry, body composifion, glucose/insulin tolerance, insulin acfion, substrate metabolism and oxidative capacity, mitochondrial funcfion, circulafing and fissue lipids (lipidomics), circulafing hormones / adipokines / cytokines, and diabetes complicafions. The MMPC maintains a fissue bio-bank as well as a comprehensive database of standard protocols for a vast number of phenotyping techniques, and phenotypic outcomes for a wide variety of genefically engineered mice. The MMPC leadership includes top investigators from the fields of nuclear receptor biology, lipid metabolism, inflammafion, and adipocyte and skeletal muscle biology including: Peter Tontonoz, Andrea Hevener, Karen Reue, Rajendra Tangirala, Edward Dennis, Oswald Quehenberger. Strengths of the MMPC include the well-rounded and complementary expertise of its leadership and the excepfional track record of producfivity and high impact scientific publicafions. The collaborafive spirit ofthe MMPC team fosters a collegial environment and supports service well-coordinated with other DRC cores and institufional resources. The central goal ofthe MMPC is to advance the scientific capabilifies ofthe DRC membership in leading-edge metabolic analysis to improve overall research quality with enhanced translafiori of research ideas from cell, fissue and mouse to man.

Public Health Relevance

The UCSD-UCLA Metabolic and Molecular Physiology Core provides DRC investigators studying obesity, diabetes and diabetes-related complications access to novel, state-of-the-art in vivo and molecular analyses of metabolism, insulin action and inflammation, thus improving overall research quality and impact by enahncing translation of scientific ideas from cell, tissue and mouse to man.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK063491-12
Application #
8641340
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
12
Fiscal Year
2014
Total Cost
$327,904
Indirect Cost
$39,840
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sen, Supriya; Langiewicz, Magda; Jumaa, Hassan et al. (2015) Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology 61:171-83
Chung, H; Lee, Y S; Mayoral, R et al. (2015) Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene 34:3504-13
Adar, Sara D; Kaufman, Joel D; Diez-Roux, Ana V et al. (2015) Air pollution and percent emphysema identified by computed tomography in the Multi-Ethnic study of Atherosclerosis. Environ Health Perspect 123:144-51
Weizman, Adam; Huang, Brian; Berel, Dror et al. (2014) Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients. Inflamm Bowel Dis 20:525-33
Baker, Michael E; Hardiman, Gary (2014) Transcriptional analysis of endocrine disruption using zebrafish and massively parallel sequencing. J Mol Endocrinol 52:R241-56
Huang, Jie; Huffman, Jennifer E; Yamakuchi, Munekazu et al. (2014) Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol 34:1093-101
Bis, Joshua C; White, Charles C; Franceschini, Nora et al. (2014) Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet 7:359-64
Tang, Wenbo; Kowgier, Matthew; Loth, Daan W et al. (2014) Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. PLoS One 9:e100776
Lubitz, Steven A; Lunetta, Kathryn L; Lin, Honghuang et al. (2014) Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. J Am Coll Cardiol 63:1200-10
Nalls, Mike A; Pankratz, Nathan; Lill, Christina M et al. (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 46:989-93

Showing the most recent 10 out of 323 publications