The Histopathology Core provides a wide spectrum of histology and microscopy services to meet the growing needs of diabetes researchers at Columbia University and affiliated institutions. Over the previous funding cycle, due to ovenwhelming demand for these essential services, the histopathology laboratory (formerly part of the Phenotyping core) and microscopy services (formeriy part of the Genomics core) have been consolidated into a new Histopathology Core. The services of this new core include the high quality basic histological and microscopy services offered in the previous funding cycle, but have been expanded to accommodate the changing and growing needs of DRC users and to incorporate newly developed reagents and technologies. Furthermore, Dr. Sussel, a leader in islet biology and pancreas development was recruited to Columbia University and the Berrie Diabetes Center in 2008 and was enlisted to develop and direct this new core. Since its establishment in 2008, the Histopathology Core has assisted 32 DRC investigators supported by 69 grants and 6 non-DRC investigators on projects that have resulted in 61 papers (29 as primary Core) and/or provided data that helped investigators obtain 14 new grants. It has processed 30,000 samples, cut -300,000 sections and performed 36,000 immunohistochemical stains, nearly 18,000 of which by immunofluorescence. The Core plans to continue to provide advanced histophenotyping capabilities to the thriving Columbia University diabetes research community. To this end, the Core will seamlessly integrated its operation with that of the other DRC Core facilities, to maintain an investigator-oriented approach to service and development, implement and sustain effective business practices, and assist the DRC in its overall mission.

Public Health Relevance

Tissue phenotyping is an essential component of analytical tools to understand, diagnose, and treat diabetes. The purpose of this facility is to ease access to complex, time-consuming, and technically intensive procedures to assist DRC investigators, accelerate discovery, streamline practices, and reduce costs and animal use.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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Columbia University (N.Y.)
New York
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Haeusler, Rebecca A; Hartil, Kirsten; Vaitheesvaran, Bhavapriya et al. (2014) Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. Nat Commun 5:5190
Censani, Marisa; Conroy, Rushika; Deng, Liyong et al. (2014) Weight loss after bariatric surgery in morbidly obese adolescents with MC4R mutations. Obesity (Silver Spring) 22:225-31
Zhang, Yiying; Zitsman, Jeffrey L; Hou, Jue et al. (2014) Fat cell size and adipokine expression in relation to gender, depot, and metabolic risk factors in morbidly obese adolescents. Obesity (Silver Spring) 22:691-7
Arora, Nidhi; Papapanou, Panos N; Rosenbaum, Michael et al. (2014) Periodontal infection, impaired fasting glucose and impaired glucose tolerance: results from the Continuous National Health and Nutrition Examination Survey 2009-2010. J Clin Periodontol 41:643-52
Morabito, Michael V; Berman, Diego E; Schneider, Remy T et al. (2014) Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease. Neurobiol Dis 65:188-92
Thai, Ashley; Papapanou, Panos N; Jacobs Jr, David R et al. (2014) Periodontal infection and cardiorespiratory fitness in younger adults: results from continuous national health and nutrition examination survey 1999-2004. PLoS One 9:e92441
Ericksen, Russell E; Rose, Shannon; Westphalen, Christoph Benedikt et al. (2014) Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response. Gut 63:385-94
Dutia, Roxanne; Brakoniecki, Katrina; Bunker, Phoebe et al. (2014) Limited recovery of *-cell function after gastric bypass despite clinical diabetes remission. Diabetes 63:1214-23
Heinrich, Garrett; Meece, Kana; Wardlaw, Sharon L et al. (2014) Preserved energy balance in mice lacking FoxO1 in neurons of Nkx2.1 lineage reveals functional heterogeneity of FoxO1 signaling within the hypothalamus. Diabetes 63:1572-82
Kode, Aruna; Manavalan, John S; Mosialou, Ioanna et al. (2014) Leukaemogenesis induced by an activating ?-catenin mutation in osteoblasts. Nature 506:240-4

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