The chain of responsibility for decision-making and administration is diagrammed in Fig. 7: The Principal Investigator of the MTCC, R.C. Boucher, will be assisted in all activities by the Co-Directors, R.J. Samulski, P. Monahan, and J. Olsen. All Projects and Cores will report directly to the Principal Investigator and Co-Directors. The Principal Investigator and Co-Directors will be advised on a yearly basis by an External Advisory Board. In deference to the competitive review process, the three new members of the External Advisory Board for the next cycle will not be announced now. We project that the advisors will be experts in gene transfer vectors, cell biology of target epithelia, and translational research. The Principal Investigator and Co-Directors will also be advised on Program progress and direction on a twice-yearly basis by an Internal Advisory Committee (hereafter defined as the """"""""Governance Committee""""""""). The Internal Advisory Committee consists of the following individuals from UNC: 1) Dr. Rudolph Juliano, Professor of Pharmacology and Pharmacy, an expert in nanotechnology;2) Dr. Beverly Koller, Department of Genetics, an expert on mouse models of disease;and 3) Dr. Xiao Xiao, Professor of Pharmacy, and an expert in gene transfer vectors. The primary role of the Advisory Committees will be to monitor the scientific progress and quality of each Pilot and Feasibility (P&F) project, and the interrelationship between Cores and the activities of the UNC-CH gene transfer community. Any major programmatic changes, or changes in leadership, if replacement of the Director or a Co-Director becomes necessary, will be decided by these committees in consultation with the NIDDK staff.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Duncan, Gregg A; Kim, Namho; Colon-Cortes, Yanerys et al. (2018) An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy. Mol Ther Methods Clin Dev 9:296-304
Gentzsch, Martina; Mall, Marcus A (2018) Ion Channel Modulators in Cystic Fibrosis. Chest 154:383-393
Terryah, Shawn T; Fellner, Robert C; Ahmad, Saira et al. (2018) Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease. Am J Physiol Lung Cell Mol Physiol 314:L192-L205
Gillen, Austin E; Yang, Rui; Cotton, Calvin U et al. (2018) Molecular characterization of gene regulatory networks in primary human tracheal and bronchial epithelial cells. J Cyst Fibros 17:444-453
Muhlebach, Marianne S; Zorn, Bryan T; Esther, Charles R et al. (2018) Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children. PLoS Pathog 14:e1006798
Cholon, Deborah M; Gentzsch, Martina (2018) Recent progress in translational cystic fibrosis research using precision medicine strategies. J Cyst Fibros 17:S52-S60
Porrello, Alessandro; Leslie, Patrick L; Harrison, Emily B et al. (2018) Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nat Commun 9:1988
Trimble, Aaron T; Whitney Brown, A; Laube, Beth L et al. (2018) Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis. J Cyst Fibros 17:650-656
Panganiban, Ronald A; Sun, Maoyun; Dahlin, Amber et al. (2018) A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis. J Allergy Clin Immunol 142:1469-1478.e2
Muhlebach, Marianne S; Hatch, Joseph E; Einarsson, Gisli G et al. (2018) Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study. Eur Respir J 52:

Showing the most recent 10 out of 133 publications