The development and validation of biomarkers that reflect different aspects of clinical disease and cystic fibrosis are of paramount importance to continued efforts to understand disease biology and the development of new therapeutics. Here, we propose the creation of a new Clinical Translation Core that will greatly facilitate these efforts. The collection of human samples including sputum, bronchoscopic specimens, exhaled breath condensate, nasal epithelia, and rectal biopsies will be expertly collected by trained personnel and linked to standardize clinical data. In addition to supporting needs of specific projects, collection of commonly used specimens (e.g. sputum and BAL) will occur in an ongoing fashion to build a specimen repository. The Clinical Translational Core will also advance the development of novel imaging biomarkers, including mucociliary clearance and 19F/1H-MRI thoracic imaging. These modalities will provide important insights into not only lung structure but also spatial representation of key physiologic functions. Finally, this Core will assist other CF RTCC investigators by providing expert guidance and assistance with trial design and conduct, subject recruitment, data management and analysis. As a whole, the clinical translation core will support a large number of investigators who are focused on understanding CF disease pathogenesis and developing new therapeutic approaches while also bringing new, needed endpoints to CF clinical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK065988-12
Application #
9058036
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
12
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Panganiban, Ronald A; Sun, Maoyun; Dahlin, Amber et al. (2018) A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis. J Allergy Clin Immunol 142:1469-1478.e2
Muhlebach, Marianne S; Hatch, Joseph E; Einarsson, Gisli G et al. (2018) Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study. Eur Respir J 52:
Ghaedi, Mahboobe; Le, Andrew V; Hatachi, Go et al. (2018) Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix. J Tissue Eng Regen Med 12:e1623-e1635
Livraghi-Butrico, Alessandra; Wilkinson, Kristen J; Volmer, Allison S et al. (2018) Lung disease phenotypes caused by overexpression of combinations of ?-, ?-, and ?-subunits of the epithelial sodium channel in mouse airways. Am J Physiol Lung Cell Mol Physiol 314:L318-L331
Chen, Gang; Volmer, Allison S; Wilkinson, Kristen J et al. (2018) Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice. Am J Respir Cell Mol Biol 59:383-396
Goralski, Jennifer L; Wu, Dan; Thelin, William R et al. (2018) The in vitro effect of nebulised hypertonic saline on human bronchial epithelium. Eur Respir J 51:
Hussain, Shah S; George, Shebin; Singh, Shashi et al. (2018) A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells. Sci Rep 8:13796
Agostini, Maria L; Andres, Erica L; Sims, Amy C et al. (2018) Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio 9:
Tomati, Valeria; Caci, Emanuela; Ferrera, Loretta et al. (2018) Thymosin ?-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia. JCI Insight 3:
Kim, Christine Seulki; Ahmad, Saira; Wu, Tongde et al. (2018) SPLUNC1 is an allosteric modulator of the epithelial sodium channel. FASEB J 32:2478-2491

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