During the past 5 years, the mandate of the Animal Models and Phenotyping Core (AMPC) was to make transgenic and gene knockout mouse production and metabolic and behavioral phenotyping readily accessible, both technically and financially, to obesity and nutrition researchers. We feel that this objective was achieved as reflected by member satisfaction with the pricing for services provided, as well as the number of transgenic and gene knockout projects completed, papers published and grants obtained. In addition, the AMPC serves as a focal point through which information on genetic engineering techniques has flowed and collaborative arrangements between investigators have been initiated. We summarize the overarching benefits provided by the investment of NORC funds in the Animal Models and Phenotyping Core, below: As a unique feature and unlike most other cores, we offer a 'turn-key' service for generating knockout mice at a price well below commercial cost ($10,000 vs $50,000) for NORC investigators. * By having a full time person (funded solely from the NORC) devoted to the design and construction of the targeting vector, we have created an efficient, money saving service for NORC investigators. * We successfully produced mice carrying floxed alleles for faculty at Pennington Biomedical Research Center, LSU (Health Science Centers at New Orleans and Shreveport and the School of Veterinary Medicine), University of Tennessee, Virginia Polytechnical Institute, University of Arizona and Scripps Research Institute. * In addition to the generation of mice, we offer state-of-the-art metabolic and behavioral phenotyping services. We have assisted investigators at the PBRC and other LSU campuses with study design, training in the use of Core equipment, execution of experiments for them, and assistance in analyzing and summarizing the collected data. * More than 60 publications resulted from this Core's support of research by NORC members. * 11 new projects were funded based on preliminary data from this Core. * More than 30 investigators accessed the services of the Core. The Core established itself as an important service provider and supported scientists at more than 8 institutions across the US, thus increasing collaboration among investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072476-08
Application #
8565054
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (M2))
Project Start
2005-09-15
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$271,849
Indirect Cost
$88,167
Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808
Yu, Sangho; Qualls-Creekmore, Emily; Rezai-Zadeh, Kavon et al. (2016) Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis. J Neurosci 36:5034-46
Correa, John B; Apolzan, John W; Shepard, Desti N et al. (2016) Evaluation of the ability of three physical activity monitors to predict weight change and estimate energy expenditure. Appl Physiol Nutr Metab 41:758-66
Na, Ha-Na; Hegde, Vijay; Dubuisson, Olga et al. (2016) E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling. PLoS One 11:e0161275
Covington, Jeffrey D; Tam, Charmaine S; Bajpeyi, Sudip et al. (2016) Myokine Expression in Muscle and Myotubes in Response to Exercise Stimulation. Med Sci Sports Exerc 48:384-90
Carvajal-Aldaz, Diana G; Guice, Justin L; Page, Ryan C et al. (2016) Simultaneous delivery of antibiotics neomycin and ampicillin in drinking water inhibits fermentation of resistant starch in rats. Mol Nutr Food Res :
Zhang, Yong; Zhao, Zhiyun; Ke, Bilun et al. (2016) Induction of Posttranslational Modifications of Mitochondrial Proteins by ATP Contributes to Negative Regulation of Mitochondrial Function. PLoS One 11:e0150454
Apolzan, John W; Myers, Candice A; Cowley, Amanda D et al. (2016) Examination of the reliability and validity of the Mindful Eating Questionnaire in pregnant women. Appetite 100:142-51
Dasuri, Kalavathi; Zhang, Le; Kim, Sun O K Fernandez et al. (2016) Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain. Biochim Biophys Acta 1862:274-83
Covington, Jeffrey D; Tam, Charmaine S; Pasarica, Magdalena et al. (2016) Higher circulating leukocytes in women with PCOS is reversed by aerobic exercise. Biochimie 124:27-33
Rundle, Andrew G; Heymsfield, Steven B (2016) Can Walkable Urban Design Play a Role in Reducing the Incidence of Obesity-Related Conditions? JAMA 315:2175-7

Showing the most recent 10 out of 612 publications