The Administrative Component is responsible for coordinating Pilot &Feasibility Projects, Scientific Core Facilities, Enrichment, and all other activities of the P30 Center. Drs. Sorscher, Kirk and the Business Officer (Ms. Diane Baer) oversee day-to-day administrative operations, and arrange for planning, evaluation, and peer review. The objective of the Administrative Core is to provide effective and integrated processes for our CF Research Base.
Specific Aims are as follows:
Specific Aim 1. To assure smooth and coordinated operation of all P30 components. This includes ongoing assessment of the most effective ways to best serve CF investigators participating in the Center.
Specific Aim 2. To carry out P30 administrative responsibilities set forth by NIH and the University of Alabama at Birmingham. This includes budgeting, monitoring, assessment and reporting requirements associated with the Center grant. In order to accomplish these objectives, the Administrative Core implements recommendations from both internal and external advisors. P30 leadership and advisory committees assure optimal use of Center resources in a fashion that promotes synergy between P30 Components and among the UAB Research Base.
During the current funding cycle, the Administrative Core has worked diligently to assure efficient operation of the NIH Center. Core leadership is experienced and strongly committed to maintaining a rigorous, collaborative, and multidisciplinary research environment. The Core has provided dedicated leadership in these areas, and is well positioned to continue in this capacity in the future.
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|Lee, Seakwoo; Henderson, Mark J; Schiffhauer, Eric et al. (2014) Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools. Mol Cell Biol 34:2554-65|
|Oren, Yifat S; McClure, Michelle L; Rowe, Steven M et al. (2014) The unfolded protein response affects readthrough of premature termination codons. EMBO Mol Med 6:685-701|
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|Zhang, Shaoyan; Ranganath, Neel K; Skinner, Daniel et al. (2014) Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model. J Cyst Fibros 13:351-2|
|Boyle, Michael P; Bell, Scott C; Konstan, Michael W et al. (2014) A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial. Lancet Respir Med 2:527-38|
|Tuggle, Katherine L; Birket, Susan E; Cui, Xiaoxia et al. (2014) Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. PLoS One 9:e91253|
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