The Administrative Component is responsible for coordinating Pilot &Feasibility Projects, Scientific Core Facilities, Enrichment, and all other activities of the P30 Center. Drs. Sorscher, Kirk and the Business Officer (Ms. Diane Baer) oversee day-to-day administrative operations, and arrange for planning, evaluation, and peer review. The objective of the Administrative Core is to provide effective and integrated processes for our CF Research Base.
Specific Aims are as follows:
Specific Aim 1. To assure smooth and coordinated operation of all P30 components. This includes ongoing assessment of the most effective ways to best serve CF investigators participating in the Center.
Specific Aim 2. To carry out P30 administrative responsibilities set forth by NIH and the University of Alabama at Birmingham. This includes budgeting, monitoring, assessment and reporting requirements associated with the Center grant. In order to accomplish these objectives, the Administrative Core implements recommendations from both internal and external advisors. P30 leadership and advisory committees assure optimal use of Center resources in a fashion that promotes synergy between P30 Components and among the UAB Research Base.

Public Health Relevance

During the current funding cycle, the Administrative Core has worked diligently to assure efficient operation of the NIH Center. Core leadership is experienced and strongly committed to maintaining a rigorous, collaborative, and multidisciplinary research environment. The Core has provided dedicated leadership in these areas, and is well positioned to continue in this capacity in the future.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-7 (J1))
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University of Alabama Birmingham
United States
Zip Code
Heltshe, Sonya L; Rowe, Steven M; Mayer-Hamblett, Nicole (2014) Evaluating the predictive ability of sweat chloride. J Cyst Fibros 13:118
Hill, Aubrey E; Plyler, Zackery E; Tiwari, Hemant et al. (2014) Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA. PLoS One 9:e109186
Dean, Nichole; Ranganath, Neel K; Jones, Brandon et al. (2014) Porcine nasal epithelial cultures for studies of cystic fibrosis sinusitis. Int Forum Allergy Rhinol 4:565-70
Lee, Seakwoo; Henderson, Mark J; Schiffhauer, Eric et al. (2014) Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools. Mol Cell Biol 34:2554-65
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Xue, Xiaojiao; Mutyam, Venkateshwar; Tang, Liping et al. (2014) Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor. Am J Respir Cell Mol Biol 50:805-16
McClure, Michelle L; Wen, Hui; Fortenberry, James et al. (2014) S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment. Biochem J 459:417-25
Zhang, Shaoyan; Ranganath, Neel K; Skinner, Daniel et al. (2014) Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model. J Cyst Fibros 13:351-2
Boyle, Michael P; Bell, Scott C; Konstan, Michael W et al. (2014) A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial. Lancet Respir Med 2:527-38
Tuggle, Katherine L; Birket, Susan E; Cui, Xiaoxia et al. (2014) Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. PLoS One 9:e91253

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