Nutrigenomics is a rapidly emerging field that studies the interface between nutrients and genomics. The study of nutrigenomics attempts to relate the processes affecting nutrient metabolism to particular genes or alternatively, to identify specific genes associated with a nutrition-related endpoint and then assess how its relation to nutrient metabolism. Insights derived from nutrigenomics will form the basis of individualized approaches to nutrition, or 'personalized nutrition.' The purpose of the Molecular Genetics and Nutrigenomics (MGN) Core is to provide services and support for basic science and clinical investigators that will enhance our understanding of the molecular and genetic basis of nutrient metabolism and the risk of chronic disease during aging. Elucidation of the genetic underpinnings of nutrition-related diseases and traits may provide key mechanistic insights that may lead to more effective prevention and treatment for these common diseases. To achieve these goals, the MGN Core will provide services to members of the Mid-Atlantic NORC in molecular genetics, genomics, and genetic epidemiology. Additionally, the Core will provide instruction and technical support to NORC users. The services to be provided by the MGN Core wil be in the areas of: (1) molecular genetics (DNA extraction, genotyping, sequencing, mutation detection);(2) molecular genomics (high through SNP genotyping and data processing);(3) and genetic epidemiology (study design, power calcuations, analysis for linkage and association studies, bioinformatics support for GWAS studies, and data mining). The MGN Core was designed to complement services available in other Cores by providing expertise and support to Center investigators to carry out genetic and genomic studies of obesity and other nutrition-related chronic diseases that can be translated into clinical studies to assess gene by environment interactions with support from the CTR Core, and pursued through basic mechanism studies to assess molecular and cellular level mechanisms with support from the ABBM Core. The extensive use and productivity of the MGN Core in the last five years demonstrates the enrichment it provides to ongoing studies by providing Center investigators with ready access to a wide range of services, promoting cross-disciplinary interactions among Center investigators, and educating students, fellows and junior faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072488-08
Application #
8380282
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$234,224
Indirect Cost
$64,962
Name
University of Maryland Baltimore
Department
Type
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Kleinberger, Jeffrey W; Copeland, Kenneth C; Gandica, Rachelle G et al. (2018) Monogenic diabetes in overweight and obese youth diagnosed with type 2 diabetes: the TODAY clinical trial. Genet Med 20:583-590
Benador, Ilan Y; Veliova, Michaela; Mahdaviani, Kiana et al. (2018) Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab 27:869-885.e6
Xu, Huichun; Dorn 2nd, Gerald W; Shetty, Amol et al. (2018) A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans. J Pers Med 8:
Craig Wood, G; Horwitz, Daniel; Still, Christopher D et al. (2018) Performance of the DiaRem Score for Predicting Diabetes Remission in Two Health Systems Following Bariatric Surgery Procedures in Hispanic and non-Hispanic White Patients. Obes Surg 28:61-68
Gu, Chenjuan; Jun, Jonathan C (2018) Does Hypoxia Decrease the Metabolic Rate? Front Endocrinol (Lausanne) 9:668
Blanco, Natalia; Johnson, J Kristie; Sorkin, John D et al. (2018) Transmission of resistant Gram-negative bacteria to healthcare personnel gowns and gloves during care of residents in community-based nursing facilities. Infect Control Hosp Epidemiol 39:1425-1430
Lent, Michelle R; Avakoff, Elizabeth; Hope, Nicholas et al. (2018) Clinical Characteristics of Roux-en-Y Gastric Bypass Patients with Death from Accidental Overdose or Intentional Self-Harm: a Descriptive Study. Obes Surg 28:3531-3537
Sung, Yun J (see original citation for additional authors) (2018) A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet 102:375-400
Lent, Michelle R; Benotti, Peter N; Wood, G Craig (2018) Response to comment on Lent et al. All-Cause and Specific-Cause Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes. Diabetes Care 2017;40:1379-1385. Diabetes Care 41:e20
Spanakis, Elias K; Levitt, David L; Siddiqui, Tariq et al. (2018) The Effect of Continuous Glucose Monitoring in Preventing Inpatient Hypoglycemia in General Wards: The Glucose Telemetry System. J Diabetes Sci Technol 12:20-25

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