The CNRU of Maryland will focus on the influence of nutrition and exercise on risk for age-related chronic diseases, including obesity, type 2 diabetes, hypertension, cardiovascular disease (CVD), sleep disordered breathing, and osteoporosis. With the obesity epidemic, associated co-morbidities now detract from the quality of life for the majority of Americans and represent a major burden to our health care system. Our research base brings together 44 investigators working on nutrition-related research at three institutions (University of Maryland, Johns Hopkins University, and U.S. Department of Agriculture, Beltsville), with multidisciplinary expertise and a strong track record of collaboration and NIH funding. To identify and evaluate the important genes that predict biological responses to diet (nutrigenomics) and exercise, our multidisciplinary research team utilizes the full spectrum of human genetics research from recruitment and phenotyping to high throughput molecular genetics to state-of-the-art statistical genetic analyses. Our team also has extensive experience in clinical and translational research, testing diet and exercise interventions to treat central obesity and the metabolic syndrome. Bridging genetics and clinical and translational research, a critical mass of investigators conduct basic research into the mechanisms regulating adipose tissue function. A cross-cutting theme of many research collaborations is understanding the genetic and nutritional contributors to high prevalence of obesity and its co-morbidities in minority populations, particularly African-Americans. Additionally, researchers address the genetic and environmental control of bone density and stroke risk and translational research to examine genetic and nutritional factors that increase risk of, and recovery from, hip fracture and stroke. The proposed Maryland CNRU will provide infrastructure and resources to expand the scope of our collaborative research efforts and to expedite new discoveries in nutrition-related research. The CNRU is organized into (Genetics;Interventions;Adipocyte Biology), (Genetics, Functional Genomics and Genetic Epidemiology;Clinical Research;Adipose Biology and Basic Mechanisms). We will also organize seminars, journal clubs, symposiums and other activities. The CNRU of Maryland will foster and facilitate research into critical issues in human nutrition and translate knowledge into effective therapies and interventions that address important health disparities in our population

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072488-10
Application #
8733155
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (M2))
Program Officer
Evans, Mary
Project Start
2005-09-15
Project End
2015-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
10
Fiscal Year
2014
Total Cost
$1,127,514
Indirect Cost
$323,655
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Coughlin, Janelle W; Brantley, Phillip J; Champagne, Catherine M et al. (2016) The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial. Obesity (Silver Spring) 24:1046-53
Kochunov, Peter; Thompson, Paul M; Winkler, Anderson et al. (2016) The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects. Neuroimage 125:189-97
Devonshire, Ashley L; Hager, Erin R; Black, Maureen M et al. (2016) Elevated blood pressure in adolescent girls: correlation to body size and composition. BMC Public Health 16:78
Lee, Jieun; Choi, Joseph; Scafidi, Susanna et al. (2016) Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation. Cell Rep 16:201-12
Kankanala, Saumya Reddy; Syed, Rafay; Gong, Quan et al. (2016) Cardiovascular safety of dipeptidyl peptidase-4 inhibitors: recent evidence on heart failure. Am J Transl Res 8:2450-8
Yerges-Armstrong, Laura M; Chai, Sumbul; O'Connell, Jeffery R et al. (2016) Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene. J Gerontol A Biol Sci Med Sci 71:1295-9
Noel, Olivier F; Still, Christopher D; Argyropoulos, George et al. (2016) Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery. J Obes 2016:4390254
Kleinberger, Jeffrey; Maloney, Kristin A; Pollin, Toni I et al. (2016) An openly available online tool for implementing the ACMG/AMP standards and guidelines for the interpretation of sequence variants. Genet Med 18:1165
Dewey, Frederick E; Gusarova, Viktoria; O'Dushlaine, Colm et al. (2016) Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease. N Engl J Med 374:1123-33
Kochunov, Peter; Fu, Mao; Nugent, Katie et al. (2016) Heritability of complex white matter diffusion traits assessed in a population isolate. Hum Brain Mapp 37:525-35

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