This is an application for renewal of a George M. O'Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center at Dallas. The Director is Dr. Peter Igarashi, Professor of Internal Medicine and Pediatrics, and Chief of the Division of Nephrology at UT Southwestern. The overall goal of the Center is to promote bidirectional interactions between basic scientists and clinical researchers that will fundamentally advance our understanding of kidney development and pathophysiology and result in more effective treatments of chronic kidney disease and it complications. To achieve this goal, the Center supports Biomedical Research Cores, Pilot &Feasibility Grants, and an Educational Enrichment Program. The four Biomedical Research Cores are: 1) Animal Models, 2) Physiology, 3) Cell Biology &Imaging, and 4) Clinical &Translational Research. The Cores support kidney research that is conducted by 49 investigators at UT Southwestern, three other academic institutions in North and Central Texas, and a foreign institution that is formally affiliated with UT Southwestern. Research is conducted in the areas of kidney development & genetics, renal physiology &pathophysiology, and chronic kidney disease. In addition, three of the Cores provide services or reagents that are widely utilized by off-campus kidney researchers located at numerous institutions throughout the U.S. and worldwide. Since its establishment in 2007, the Center has supported 111 published articles as well as new scientific collaborations and grant applications. Studies that are supported by the Center have provided new insights into the pathogenesis and treatment of congenital kidney abnormalities, polycystic kidney disease, lupus nephritis, diabetic nephropathy, electrolyte disturbances, and complications of chronic kidney disease. To expand the pool of kidney researchers, the Center awards two Pilot &Feasibility Grants per year to new investigators or established investigators from other fields. The Educational Enrichment Program includes a monthly research seminar, annual symposium, training grants, and courses offered through the Dept. of Clinical Sciences as well as practical hands-on training in each of the Cores.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK079328-07
Application #
8518303
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Kimmel, Paul
Project Start
2007-08-03
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
7
Fiscal Year
2013
Total Cost
$1,165,505
Indirect Cost
$432,483
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Gattineni, Jyothsna; Alphonse, Priyatharshini; Zhang, Qiuyu et al. (2014) Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4. Am J Physiol Renal Physiol 306:F351-8
Luo, Yanmin; Kumar, Premlata; Chen, Chien-Cheng et al. (2014) Estrogen-related receptor ? serves a role in blood pressure homeostasis during pregnancy. Mol Endocrinol 28:965-75
Lu, Christopher Y (2014) ?-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD?, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation. Kidney Int 85:496-8
Umetani, Michihisa; Ghosh, Pritam; Ishikawa, Tomonori et al. (2014) The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab 20:172-82
Zhang, Jianning; Fuster, Daniel G; Cameron, Mary Ann et al. (2014) Incomplete distal renal tubular acidosis from a heterozygous mutation of the V-ATPase B1 subunit. Am J Physiol Renal Physiol 307:F1063-71
Williams, Scott S; Cobo-Stark, Patricia; Hajarnis, Sachin et al. (2014) Tissue-specific regulation of the mouse Pkhd1 (ARPKD) gene promoter. Am J Physiol Renal Physiol 307:F356-68
Siddique, Khurrum; Guzman, German Lozano; Gattineni, Jyothsna et al. (2014) Effect of postnatal maternal protein intake on prenatal programming of hypertension. Reprod Sci 21:1499-507
Jain, Nishank; Minhajuddin, Abu T; Neeland, Ian J et al. (2014) Association of urinary sodium-to-potassium ratio with obesity in a multiethnic cohort. Am J Clin Nutr 99:992-8
Xu, Min; Nagati, Jason S; Xie, Jian et al. (2014) An acetate switch regulates stress erythropoiesis. Nat Med 20:1018-26
Rosenfeld, Charles R; Roy, Timothy (2014) Prolonged uterine artery nitric oxide synthase inhibition modestly alters basal uteroplacental vasodilation in the last third of ovine pregnancy. Am J Physiol Heart Circ Physiol 307:H1196-203

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