This is an application for renewal of a George M. O'Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center at Dallas. The Director is Dr. Peter Igarashi, Professor of Internal Medicine and Pediatrics, and Chief of the Division of Nephrology at UT Southwestern. The overall goal of the Center is to promote bidirectional interactions between basic scientists and clinical researchers that will fundamentally advance our understanding of kidney development and pathophysiology and result in more effective treatments of chronic kidney disease and it complications. To achieve this goal, the Center supports Biomedical Research Cores, Pilot &Feasibility Grants, and an Educational Enrichment Program. The four Biomedical Research Cores are: 1) Animal Models, 2) Physiology, 3) Cell Biology &Imaging, and 4) Clinical &Translational Research. The Cores support kidney research that is conducted by 49 investigators at UT Southwestern, three other academic institutions in North and Central Texas, and a foreign institution that is formally affiliated with UT Southwestern. Research is conducted in the areas of kidney development & genetics, renal physiology &pathophysiology, and chronic kidney disease. In addition, three of the Cores provide services or reagents that are widely utilized by off-campus kidney researchers located at numerous institutions throughout the U.S. and worldwide. Since its establishment in 2007, the Center has supported 111 published articles as well as new scientific collaborations and grant applications. Studies that are supported by the Center have provided new insights into the pathogenesis and treatment of congenital kidney abnormalities, polycystic kidney disease, lupus nephritis, diabetic nephropathy, electrolyte disturbances, and complications of chronic kidney disease. To expand the pool of kidney researchers, the Center awards two Pilot &Feasibility Grants per year to new investigators or established investigators from other fields. The Educational Enrichment Program includes a monthly research seminar, annual symposium, training grants, and courses offered through the Dept. of Clinical Sciences as well as practical hands-on training in each of the Cores.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK079328-08
Application #
8721928
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Kimmel, Paul
Project Start
2007-08-03
Project End
2017-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Raman, Archana; Reif, Gail A; Dai, Yuqiao et al. (2017) Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease. J Am Soc Nephrol 28:2708-2719
Yano, Yuichiro; Neeland, Ian J; Ayers, Colby et al. (2017) Hemodynamic and Mechanical Properties of the Proximal Aorta in Young and Middle-Aged Adults With Isolated Systolic Hypertension: The Dallas Heart Study. Hypertension 70:158-165
Hajarnis, Sachin; Lakhia, Ronak; Yheskel, Matanel et al. (2017) microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism. Nat Commun 8:14395
Van Buren, Peter Noel (2017) Pathophysiology and implications of intradialytic hypertension. Curr Opin Nephrol Hypertens 26:303-310
Pan, Xinchao; Karner, Courtney M; Carroll, Thomas J (2017) Myc cooperates with ?-catenin to drive gene expression in nephron progenitor cells. Development 144:4173-4182
Wang, Qian; Cobo-Stark, Patricia; Patel, Vishal et al. (2017) Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease. Kidney Int :
Sanghera, Prateek; Ghanta, Mythili; Ozay, Fatih et al. (2017) Kidney Diseases Associated With Alternative Complement Pathway Dysregulation and Potential Treatment Options. Am J Med Sci 354:533-538
Kim, Ji-Hee; Xie, Jian; Hwang, Kyu-Hee et al. (2017) Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes. J Am Soc Nephrol 28:140-151
Wu, Yueh-Lin; Xie, Jian; An, Sung-Wan et al. (2017) Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho. Kidney Int 91:830-841
Ku, Elaine; Gassman, Jennifer; Appel, Lawrence J et al. (2017) BP Control and Long-Term Risk of ESRD and Mortality. J Am Soc Nephrol 28:671-677

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