This is a renewal application for the Clinical and Translational Core of the UT Southwestern George M. O'Brien Kidney Disease Center. The long-term, broad objective of this core is to facilitate translation of basic and clinical discoveries into effective diagnostic and therapeutic strategies to improve the lives of patients with chronic kidney disease (CKD). Over the past 4.5 years we established the Core as an outstanding resource for Center investigators to conduct studies in patients with CKD including those diabetes, hypertension and glomerular diseases. Center investigators have conducted innovative, high impact cuttingedge research in diverse ethnic and racial groups to improve detection, diagnosis, prevention and treatment of those at very high risk for kidney disease progression and its complications. We now propose the following four specific aims: 1) provide expertise in study design, and protocol development and implementation including regulatory knowledge, grants and contracts, database management and biostatistics and coordination of these functions with other Cores and Center Investigators;2) provide technical and logistical support for conducting human clinical trials including study subject recruitment and retention, data collection, adverse event reporting, study drug randomization allocation and storage, body fluid collection, processing and storage for phase 1-4 clinical trials;3) develop a new assay for Klotho protein and novel renal magnetic resonance imaging methods in conjunction with the cell biology and imaging core, provide measurements of cardiovascular and renal function including central aortic and ambulatory blood pressure, flow-mediated vasodilation, creatinine and iothalamate measurements and ELISA methods for markers of kidney injury, and design and statistical analysis of human genetic studies including linkage analysis, whole-exome sequencing, and candidate gene analysis;and 4) provide educational enrichment programs for all Center investigators and their trainees. The C&T Core is critical to the overall goal of the UTSW O'Brien Kidney Center. The Core is operational and poised to promote the discovery and application of research methods leading to improved health and well-being of patients with chronic kidney disease.

Public Health Relevance

Chronic kidney disease is a major public health problem that affects nearly 13% of the United States adult population. Chronic kidney disease often progresses to kidney failure necessitating treatment with dialysis or kidney transplantation and is associated with premature death often due to cardiovascular complications such as heart attack and stroke. Development of new research methods and their application is critical to improve the detection, diagnosis, prevention and treatment of chronic kidnev disease and its complications.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30DK079328-08
Application #
8721934
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
City
Dallas
State
TX
Country
United States
Zip Code
75390
Baum, Michel (2016) Luminal angiotensin II stimulates rat medullary thick ascending limb chloride transport in the presence of basolateral norepinephrine. Am J Physiol Renal Physiol 310:F294-9
Tanriover, Bekir; MacConmara, Malcolm P; Parekh, Justin et al. (2016) SIMULTANEOUS LIVER KIDNEY TRANSPLANTATION IN LIVER TRANSPLANT CANDIDATES WITH RENAL DYSFUNCTION: IMPORTANCE OF CREATININE LEVELS, DIALYSIS, AND ORGAN QUALITY IN SURVIVAL. KI Rep 1:221-229
Zhang, Jiandong; Rudemiller, Nathan P; Patel, Mehul B et al. (2016) Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. J Am Soc Nephrol 27:2257-64
Srivastava, Anand; Adams-Huet, Beverley; Vega, Gloria L et al. (2016) Effect of losartan and spironolactone on triglyceride-rich lipoproteins in diabetic nephropathy. J Investig Med 64:1102-8
Baum, Michel (2016) Neonatal nephrology. Curr Opin Pediatr 28:170-2
Yang, Zhufeng; Zimmerman, Susan E; Tsunezumi, Jun et al. (2016) Role of CD34 family members in lumen formation in the developing kidney. Dev Biol 418:66-74
Westover, Arthur N; Nakonezny, Paul A; Barlow, Carolyn E et al. (2016) Heart Rate Recovery and Systolic Blood Pressure Recovery After Maximal Exercise in Prevalent Users of Stimulant Medications. J Clin Psychopharmacol 36:295-7
Jain, Nishank; Li, Xilong; Adams-Huet, Beverley et al. (2016) Differences in Whole Blood Platelet Aggregation at Baseline and in Response to Aspirin and Aspirin Plus Clopidogrel in Patients With Versus Without Chronic Kidney Disease. Am J Cardiol 117:656-63
Ravikumar, Priya; Menon, Jyothi U; Punnakitikashem, Primana et al. (2016) Nanoparticle facilitated inhalational delivery of erythropoietin receptor cDNA protects against hyperoxic lung injury. Nanomedicine 12:811-21
Vongpatanasin, Wanpen; Peri-Okonny, Poghni; Velasco, Alejandro et al. (2016) Effects of Potassium Magnesium Citrate Supplementation on 24-Hour Ambulatory Blood Pressure and Oxidative Stress Marker in Prehypertensive and Hypertensive Subjects. Am J Cardiol 118:849-53

Showing the most recent 10 out of 198 publications