The Human Physiology Core has had a remarkable record of productivity with increasing provision of services over the first 4 years of the DRTC. The broad, long-range objectives and goals as a DRC Core are to: ? Provide analysis of hormones, adipokines, markers of inflammation, glucose, lipids, and molecules relevant to diabetes risk and pathophysiology for both clinical and animal studies, and from both biological fluids and tissue culture specimens. Provide assessment of human insulin sensitivity, beta-cell function, and in vivo glucose metabolism. The Core provides assistance with the euglycemic clamp, the intravenous glucose tolerance test, the mixed macronutrient meal test, and the oral glucose tolerance test. Core personnel assist with drafting and implementing test protocols, and provide sample analysis, data reduction, mathematical modeling, and help with interpretation of results. ? Provide assessment of human body composition as related to diabetes risk. The Core supports measueres of visceral and subcutaneous abdominal adipose tissue, intermuscular adipose tissue, intrahepatic lipid, intramyocellular lipid, and bone marrow adipose tissue. Core peronnel assist with protocol implementation using MRI, MRS, and CT, and provide analysis of relevant tissue measures using SliceOmatic and other software as appropriate. Bone and muscle composition and density also are assessed with MRI and pQCT. The Core is equipped to assess every element of the """"""""bone-fat-pancreas"""""""" axis to advance research regarding the concept that bone metabolism affects diabetes risk. Provide assessment of cardiovascular function, including endothelial function, arterial compliance, thoracic impedance, and ambulatory blood pressure. Provide cost-effective, centralized services to ongoing funded and pilot research projects. Promote multi-disciplinary research and training in diabetes across the UAB campus. Offer training, advice, and instruction to graduate students, fellows, and investigators.

Public Health Relevance

The Human Physiology Core provides important tools for translational research related to human metabolism in the DRC. This includes assays and technologies pertaining to glucose homeostasis, insulin sensitivity, beta-cell function, and adipose tissue distribution. The Core stays abreast of developments in diabetes research technology, and responds to investigator needs by adding necessary tests and measures. The Core provides training to UAB invfistioators. and promotes interdiscinlinarv diabfites-related research.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-S (O2))
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University of Alabama Birmingham
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Jones, Kristian T; Shelton, Richard C; Wan, Jun et al. (2016) Impact of acute psychological stress on cardiovascular risk factors in face of insulin resistance. Stress 19:585-592
Wende, Adam R; Young, Martin E; Chatham, John et al. (2016) Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radic Biol Med 100:94-107
Goldsby, TaShauna U; George, Brandon J; Yeager, Valerie A et al. (2016) Urban Park Development and Pediatric Obesity Rates: A Quasi-Experiment Using Electronic Health Record Data. Int J Environ Res Public Health 13:411
Hong, Kyunghee; Xu, Guanlan; Grayson, Truman B et al. (2016) Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways. J Biol Chem 291:8428-39
Howard, George; Moy, Claudia S; Howard, Virginia J et al. (2016) Where to Focus Efforts to Reduce the Black-White Disparity in Stroke Mortality: Incidence Versus Case Fatality? Stroke 47:1893-8
Sweatt, S Katherine; Roy, Jane; Chandler-Laney, Paula et al. (2016) Ethnic differences in the consistency and accuracy of perceived exertion. Am J Hum Biol 28:398-404
Cunningham, Glenn R; Stephens-Shields, Alisa J; Rosen, Raymond C et al. (2016) Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels. J Clin Endocrinol Metab 101:3096-104
Cardel, M I; Johnson, S L; Beck, J et al. (2016) The effects of experimentally manipulated social status on acute eating behavior: A randomized, crossover pilot study. Physiol Behav 162:93-101
Krzywanski, David M; Moellering, Douglas R; Westbrook, David G et al. (2016) Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry. Circ Cardiovasc Genet 9:26-36
Quon, Bradley S; Rowe, Steven M (2016) New and emerging targeted therapies for cystic fibrosis. BMJ 352:i859

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