The overall goal of the Interventions and Translation Core (ITC) is to provide expertise and infrastructure to assist investigators with the development, implementation, and evaluation of culturally appropriate interventions. Our objective is to create new knowledge regarding the prevention and management of diabetes and cardiometabolic disease, with an emphasis on reducing health disparities. The ITC?s 3 specific aims are to: 1. Provide expert consultation for intervention development in diabetes prevention and management (e.g., interventions to optimize diet, body weight, exercise/physical activity, medication adherence, and/or glycemic control). This expertise will facilitate translation of basic science findings into efficacy-testing interventions ranging from clinical to community-based trials. 2. Provide expertise on study design and evaluation, including measurement, quality control, quality assurance, and analytic support, for research to prevent and manage diabetes. These studies will include but also go beyond traditional clinical trials. For example, group-randomized trials evaluating weight-loss interventions in community settings require specialized expertise in trial design, data capture and transfer, as well as in interventional and analytic tools. 3. Design and facilitate culturally appropriate strategies to enhance the recruitment and retention of minorities and underserved populations in diabetes-related research studies, with emphasis on African American and rural communities. These core services are based on the expressed needs of funded DRC investigators, and methods will rely on validated, state-of-the-art approaches with a high priority placed on data quality control. The ITC will leverage existing infrastructure for recruitment and community-based research and make cutting edge expertise in intervention development, implementation, and evaluation available to the DRC research base, promoting innovation and advancing the science of diabetes prevention and management.

Public Health Relevance

Research to bridge the gap that separates scientific discovery from clinical practice is sorely needed to counter the diabetes epidemic and improve diabetes related health outcomes.The ITC will provide resources and cutting edge expertise in intervention development, implementation and evaluation for researchers at UAB, to define optimal strategies for diabetes care and prevention in the heart of the Deep South.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
United States
Zip Code
Misra, Devyani; Felson, David T; Silliman, Rebecca A et al. (2015) Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative. J Gerontol A Biol Sci Med Sci 70:339-44
Panwar, Bhupesh; Hanks, Lynae J; Tanner, Rikki M et al. (2015) Obesity, metabolic health, and the risk of end-stage renal disease. Kidney Int 87:1216-22
Casazza, Krista; Brown, Andrew; Astrup, Arne et al. (2015) Weighing the Evidence of Common Beliefs in Obesity Research. Crit Rev Food Sci Nutr 55:2014-53
Harper, Lorie M; Tita, Alan; Biggio, Joseph R (2015) The institute of medicine guidelines for gestational weight gain after a diagnosis of gestational diabetes and pregnancy outcomes. Am J Perinatol 32:239-46
Cree-Green, Melanie; Newcomer, Bradley R; Brown, Mark S et al. (2015) Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes 64:383-92
Bone, Robert N; Gai, Ying; Magrioti, Victoria et al. (2015) Inhibition of Ca2+-independent phospholipase A2? (iPLA2?) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes 64:541-54
Carson, April P; Steffes, Michael W; Carr, J Jeffrey et al. (2015) Hemoglobin a1c and the progression of coronary artery calcification among adults without diabetes. Diabetes Care 38:66-71
Clement, Lionel C; Macé, Camille; Del Nogal Avila, Maria et al. (2015) The proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome. Transl Res 165:499-504
Hanks, Lynae J; Casazza, Krista; Ashraf, Ambika P et al. (2015) Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females. Clin Endocrinol (Oxf) 82:550-6
Armstrong, Anderson C; Liu, Kiang; Lewis, Cora E et al. (2014) Left atrial dimension and traditional cardiovascular risk factors predict 20-year clinical cardiovascular events in young healthy adults: the CARDIA study. Eur Heart J Cardiovasc Imaging 15:893-9

Showing the most recent 10 out of 154 publications