The Clinical Phenotyping Resource and Biobank Core (C-PROBE) ofthe University of Michigan George M. O'Brien Kidney Center is designed to expedite the application of nascent laboratory discoveries to human subjects in the quest to treat and prevent and kidney disease. The primary goal ofthe C-PROBE is to provide infrastructure that will optimize the interface between patients and biomedical investigators to streamline translational research in kidney disease.
Specific Aims : C-PROBE will 1) maintain a cohort of 1000 adult participants with kidney disease from diverse backgrounds from University of Michigan, Renaissance Renal Research Institute, University of Illinois, Chicago, Wayne State University and Temple University 2) add 300 pediatric participants with kidney disease from University of Michigan and Levine Children's Hospital, Charlotte, NC, to enhance scientific exploration and collaboration on affected individuals throughout the life span 3) provide longitudinal phenotypic characterization ofthe C-PROBE cohort (including demographic, clinical and laboratory data) utilizing a multi-dimensional relational clinical research data management system, VELOS eResearch?, to promote and support translational investigation 4) maintain a specimen biobank for the purpose of sharing and distributing urine, blood, DNA, and kidney biopsy tissue samples to biomedical research investigators according to agreed repository governance policies 5) support high-quality research by linking biostatistical and bioinformatics expertise from the Applied Systems Biology and Bioinformatics Cores to investigators engaged in ancillary studies utilizing core resources. Methods: C-PROBE will provide (a) a longitudinal cohort of well-characterized patients with kidney disease organized into a secured, web-distributed clinical research data management system;(b) a specimen repository integrated into the clinical research database for distribution and sharing with investigators according to agreed policies;(c) access to study design and analytical expertise for ancillary projects utilizing core materials. C-PROBE leverages support from the Michigan Institute for Clinical and Health Research (Michigan CTSA) to accelerate translational research productivity. .

Public Health Relevance

C-PROBE is structured and governed to optimally harness and maximize the use of resources for conducting translational research in kidney disease. Given the collaborative multi-disciplinary network of scientific expertise, this core is singularly suitable to accelerate medical advancement to address the public health burden of kidney disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-6)
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University of Michigan Ann Arbor
Ann Arbor
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Yu, Haiyang; Artomov, Mykyta; Brähler, Sebastian et al. (2016) A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis. J Clin Invest 126:1603
Venkatareddy, Madhusudan; Verma, Rakesh; Kalinowski, Anne et al. (2016) Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells. J Am Soc Nephrol 27:2702-19
Sas, Kelli M; Kayampilly, Pradeep; Byun, Jaeman et al. (2016) Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications. JCI Insight 1:e86976
Sampson, Matthew G; Robertson, Catherine C; Martini, Sebastian et al. (2016) Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects. J Am Soc Nephrol 27:814-23
Brosius, Frank C; Tuttle, Katherine R; Kretzler, Matthias (2016) JAK inhibition in the treatment of diabetic kidney disease. Diabetologia 59:1624-7
Yao, Yao; Wang, Junying; Yoshida, Sei et al. (2016) Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function. J Am Soc Nephrol 27:3653-3665
Naik, Abhijit S; Afshinnia, Farsad; Cibrik, Diane et al. (2016) Quantitative podocyte parameters predict human native kidney and allograft half-lives. JCI Insight 1:
Betz, Boris; Conway, Bryan R (2016) An Update on the Use of Animal Models in Diabetic Nephropathy Research. Curr Diab Rep 16:18
Hur, Junguk; O'Brien, Phillipe D; Nair, Viji et al. (2016) Transcriptional networks of murine diabetic peripheral neuropathy and nephropathy: common and distinct gene expression patterns. Diabetologia 59:1297-306
Saito, Rintaro; Rocanin-Arjo, Anaïs; You, Young-Hyun et al. (2016) Systems biology analysis reveals role of MDM2 in diabetic nephropathy. JCI Insight 1:e87877

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