The Clinical Phenotyping Resource and Biobank Core (C-PROBE) ofthe University of Michigan George M. O'Brien Kidney Center is designed to expedite the application of nascent laboratory discoveries to human subjects in the quest to treat and prevent and kidney disease. The primary goal ofthe C-PROBE is to provide infrastructure that will optimize the interface between patients and biomedical investigators to streamline translational research in kidney disease.
Specific Aims : C-PROBE will 1) maintain a cohort of 1000 adult participants with kidney disease from diverse backgrounds from University of Michigan, Renaissance Renal Research Institute, University of Illinois, Chicago, Wayne State University and Temple University 2) add 300 pediatric participants with kidney disease from University of Michigan and Levine Children's Hospital, Charlotte, NC, to enhance scientific exploration and collaboration on affected individuals throughout the life span 3) provide longitudinal phenotypic characterization ofthe C-PROBE cohort (including demographic, clinical and laboratory data) utilizing a multi-dimensional relational clinical research data management system, VELOS eResearch?, to promote and support translational investigation 4) maintain a specimen biobank for the purpose of sharing and distributing urine, blood, DNA, and kidney biopsy tissue samples to biomedical research investigators according to agreed repository governance policies 5) support high-quality research by linking biostatistical and bioinformatics expertise from the Applied Systems Biology and Bioinformatics Cores to investigators engaged in ancillary studies utilizing core resources. Methods: C-PROBE will provide (a) a longitudinal cohort of well-characterized patients with kidney disease organized into a secured, web-distributed clinical research data management system;(b) a specimen repository integrated into the clinical research database for distribution and sharing with investigators according to agreed policies;(c) access to study design and analytical expertise for ancillary projects utilizing core materials. C-PROBE leverages support from the Michigan Institute for Clinical and Health Research (Michigan CTSA) to accelerate translational research productivity. .

Public Health Relevance

C-PROBE is structured and governed to optimally harness and maximize the use of resources for conducting translational research in kidney disease. Given the collaborative multi-disciplinary network of scientific expertise, this core is singularly suitable to accelerate medical advancement to address the public health burden of kidney disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-6)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Afshinnia, Farsad; Zeng, Lixia; Byun, Jaeman et al. (2017) Myeloperoxidase Levels and Its Product 3-Chlorotyrosine Predict Chronic Kidney Disease Severity and Associated Coronary Artery Disease. Am J Nephrol 46:73-81
Crawford, Brendan D; Gillies, Christopher E; Robertson, Catherine C et al. (2017) Evaluating Mendelian nephrotic syndrome genes for evidence for risk alleles or oligogenicity that explain heritability. Pediatr Nephrol 32:467-476
Zhang, Jifeng; Niimi, Manabu; Yang, Dongshan et al. (2017) Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits. Arterioscler Thromb Vasc Biol 37:1068-1075
Lee, Ha Won; Khan, Samia Q; Khaliqdina, Shehryar et al. (2017) Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1. J Biol Chem 292:732-747
Lopez-Rivera, Esther; Liu, Yangfan P; Verbitsky, Miguel et al. (2017) Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. N Engl J Med 376:742-754
Lindenmeyer, Maja T; Kretzler, Matthias (2017) Renal biopsy-driven molecular target identification in glomerular disease. Pflugers Arch 469:1021-1028
Mariani, Laura H; Martini, Sebastian; Barisoni, Laura et al. (2017) Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies. Nephrol Dial Transplant :
Levin, Adeera; Tonelli, Marcello; Bonventre, Joseph et al. (2017) Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet 390:1888-1917
Shved, Natallia; Warsow, Gregor; Eichinger, Felix et al. (2017) Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts. Sci Rep 7:8576
Fukuda, Akihiro; Minakawa, Akihiro; Sato, Yuji et al. (2017) Urinary podocyte and TGF-?1 mRNA as markers for disease activity and progression in anti-glomerular basement membrane nephritis. Nephrol Dial Transplant 32:1818-1830

Showing the most recent 10 out of 157 publications