The Bioinformatics Core is an important component ofthe Michigan O'Brien Kidney Translational Core Center. This core will provide access to computational applications and skilled professional support in bioinformatics and biostatistics Increasingly large and complex data sets require computational support for analyses, and the presence of this core will enhance the research. The Bioinformatics Core will provide analytical support for large datasets including microarray, and next generations sequencing applications for genomics, transcriptomics, proteomics and epigenetics. The Bioinformatics Core is aligned to the overall goals ofthe Center and will provide focused, specific support for researchers studying chronic kidney disease. To be successful, this core will provide guidance and assistance to Center researchers at all stages of research from experimental design to data generation and analysis of molecular profiling data. The Bioinformatics Core will be fully integrated with the DNA sequencing core for smooth coordination of data transfer and analysis. The system's biology core will also be integrated with the Bioinformatics Core to provide deeper analysis ofthe project data and combine the different molecular profiling analyses.
Bioinformatics and biostatistics are essential for the analysis and interpretation of large data sets. The inclusion of this core to the Michigan O'Brien center is crucial to providing complete support for chronic kidney disease researchers.
|Sampson, Matthew G; Hodgin, Jeffrey B; Kretzler, Matthias (2015) Defining nephrotic syndrome from an integrative genomics perspective. Pediatr Nephrol 30:51-63; quiz 59|
|Beeken, Maire; Lindenmeyer, Maja T; Blattner, Simone M et al. (2014) Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases. J Am Soc Nephrol 25:2511-25|
|Cui, Shuaiying; Tanabe, Osamu; Lim, Kim-Chew et al. (2014) PGC-1 coactivator activity is required for murine erythropoiesis. Mol Cell Biol 34:1956-65|
|Yamazaki, Hiromi; Suzuki, Mikiko; Otsuki, Akihito et al. (2014) A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. Cancer Cell 25:415-27|
|Niewczas, Monika A; Sirich, Tammy L; Mathew, Anna V et al. (2014) Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study. Kidney Int 85:1214-24|
|Brosius, Frank C; Coward, Richard J (2014) Podocytes, signaling pathways, and vascular factors in diabetic kidney disease. Adv Chronic Kidney Dis 21:304-10|
|Dessapt-Baradez, Cecile; Woolf, Adrian S; White, Kathryn E et al. (2014) Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease. J Am Soc Nephrol 25:33-42|
|Shi, Lihong; Lin, Yu-Hsuan; Sierant, M C et al. (2014) Developmental transcriptome analysis of human erythropoiesis. Hum Mol Genet 23:4528-42|
|Martini, Sebastian; Nair, Viji; Keller, Benjamin J et al. (2014) Integrative biology identifies shared transcriptional networks in CKD. J Am Soc Nephrol 25:2559-72|
|Shi, Lihong; Sierant, M C; Gurdziel, Katherine et al. (2014) Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells. PLoS Genet 10:e1004339|
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