The DDBTRCC Translational Research Enhancement Core (Core D) has as its goal to make translating basic research findings made by the Core Center Research Base and other JHUSOM investigators easier and more efficient to achieve. The JHUSOM GI Division had been carrying out translational research involving human tissues ofthe GI tract but without an organized structure. In November 2006, the GI Division established the concept of a tissue repository with the understanding that the uniform and standardized harvest of biospecimens with associated, comprehensive clinical and epidemiological data would greatly facilitate and improve the study of gastrointestinal disease processes. The two main components of this repository were the Clinical Research Unit to record the clinical data and the Tissue Bank which holds the patient DNA, RNA and tissue specimens. Combined, these two integrated units provide a cost-effective, efficient centralized tissue banking system to provide high quality, clinical data-associated specimens to multiple users for individual research projects and for fostering collaborations among multiple users. Support for Core D partially supports the Core Director who is the JHUSOM faculty member who is most knowledgeable about tissue repositories as well as a technician who helps obtain and process the biological specimens for our Research Base. Initial support is only for projects by our Research Base which are hypothesis driven, IRB approved and extramurally funded. This Core will provide the infrastructure for the cost-effective tissue and clinical data collection that meets Best Practices through the establishment of uniform Standard Operating Procedures (SOPs) to promote scientific advances by and scientific interactions among Core users, collaborative investigators and young investigators, without each investigator having to invest in the equipment/resources or individually work out specific SOPs.

Public Health Relevance

The DDBTRCC Translational Research Enhancement Core (Core D) has as its goal to make translating basic research findings made by the Core Center Research Base and other JHUSOM investigators easier and more efficient to achieve by investing in a Core in which the clinical data are recorded and specimens are uniformly banked

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-8)
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Johns Hopkins University
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Pierson, Hannah; Muchenditsi, Abigael; Kim, Byung-Eun et al. (2018) The Function of ATPase Copper Transporter ATP7B in Intestine. Gastroenterology 154:168-180.e5
Kim, Sangjune; Yun, Seung Pil; Lee, Saebom et al. (2018) GBA1 deficiency negatively affects physiological ?-synuclein tetramers and related multimers. Proc Natl Acad Sci U S A 115:798-803
Pilla, Scott J; Maruthur, Nisa M; Schweitzer, Michael A et al. (2018) The Role of Laboratory Testing in Differentiating Type 1 Diabetes from Type 2 Diabetes in Patients Undergoing Bariatric Surgery. Obes Surg 28:25-30
Rajkumar, Premraj; Cha, Boyoung; Yin, Jianyi et al. (2018) Identifying the localization and exploring a functional role for Gprc5c in the kidney. FASEB J 32:2046-2059
Pilla, Scott J; Yeh, Hsin-Chieh; Juraschek, Stephen P et al. (2018) Predictors of Insulin Initiation in Patients with Type 2 Diabetes: An Analysis of the Look AHEAD Randomized Trial. J Gen Intern Med 33:839-846
Yin, Jianyi; Tse, Chung-Ming; Avula, Leela Rani et al. (2018) Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. Cell Mol Gastroenterol Hepatol 5:591-609
Kulkarni, Subhash; Ganz, Julia; Bayrer, James et al. (2018) Advances in Enteric Neurobiology: The ""Brain"" in the Gut in Health and Disease. J Neurosci 38:9346-9354
Bhattarai, Yogesh; Williams, Brianna B; Battaglioli, Eric J et al. (2018) Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell Host Microbe 23:775-785.e5
Avula, Leela Rani; Chen, Tiane; Kovbasnjuk, Olga et al. (2018) Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid. Am J Physiol Gastrointest Liver Physiol 314:G81-G90
Moinova, Helen R; LaFramboise, Thomas; Lutterbaugh, James D et al. (2018) Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus. Sci Transl Med 10:

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