The Hopkins Digestive Diseases Basic and Translational Research Core Center Administrative Core is the glue which forms the structure of this Center by carrying out communications among the Center and Research Base investigators and Core Directors, performing budget management, serving as a repertoire for the software used by Center investigators and organizing all Center activities. In this way the Research Base of 50 investigataors (38 full members 12 associate members) are allowed to efficiently interact with the components ofthe Core Center, including the a) Administrative Core;b) 4 Scientific Cores-3 basic science [1) Proteomics;2) Imaging;3) Mouse Physiology] and a Translational Research Enhancement Core;c) Pilot Project Program;d) Enrichement Program which has multiple components. The specific functions ofthe Administrative Core include: a) Provide administrative and financial management ofthe Core Center;b) Provide monthly financial statements to Core Directors;c) Monitor use and perform charge-back for each Core 6x year;d) Inform Research Base weekly of work-in-progress meeting topic, lectures of interest around Hopkins, NIH funding opportunities, GI histology findings on mouse models studied by Research Base, Visiting Professor Program, Yearly Scientic Symposium, Yearly Retreat;e) Arrange a yearly meeting of External Scientific Advisory Committee, every other month meeting of Internal Executive Committee and Focus Groups, 6x year Visiting Professor Program, and yearly working group meetings for each Core;f) Organize and run yearly Research Base one day retreat;g) Organize and run yearly 1-2 day long Research Symposium;h) Organize and publish yearly Core Center newsletter;i) Assist in preparation of yearly DDBTRCC Progress Report for NIH;j) Prepare notes from yearly External Scientific Advisory Committee meeting;k) Organize and administer Pilot Project Program;1) Organize and administer Mini-Sabbatical Program;m) Help Research Base comply with JHUSOM, NIH, other governmental guidelines relating to research;n) Develop web page for Imaging and Mouse Physiology Cores;o) Help manage DDBTRCC service contracts;p) Help negotiate Core Center purchasing of equipment, service contracts, software; q) Serve as a repository for licenses for software purchased for Research Base and Core use.

Public Health Relevance

The Administrafive core is the glue which forms the structure of this Core Center by communicating Core Center activities to the Research Base investigators. Core Directors, and Core Center leadership, performing budget management and serving as the site of storage of the Core Center software that is made available to the Research Base.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
United States
Zip Code
Llosa, Nicolas J; Cruise, Michael; Tam, Ada et al. (2015) The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov 5:43-51
Cha, Boyoung; Chen, Tiane; Sarker, Rafiquel et al. (2014) Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKC? signaling. Am J Physiol Cell Physiol 307:C55-65
Gabelli, Sandra B; Boto, Agedi; Kuhns, Victoria Halperin et al. (2014) Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nat Commun 5:5126
Miller, Michelle S; Schmidt-Kittler, Oleg; Bolduc, David M et al. (2014) Structural basis of nSH2 regulation and lipid binding in PI3K?. Oncotarget 5:5198-208
Yang, Jianbo; Singh, Varsha; Chen, Tian-E et al. (2014) NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol. J Biol Chem 289:20039-53
Singh, Varsha; Yang, Jianbo; Chen, Tiane-e et al. (2014) Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clin Gastroenterol Hepatol 12:27-31
Singh, Varsha; Lin, Rong; Yang, Jianbo et al. (2014) AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking. J Biol Chem 289:5449-61
Chen, Tiane; Hubbard, Ann; Murtazina, Rakhilya et al. (2014) Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells. J Cell Sci 127:3535-45
Foulke-Abel, Jennifer; In, Julie; Kovbasnjuk, Olga et al. (2014) Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood) 239:1124-34
Herbrich, Shelley M; Cole, Robert N; West Jr, Keith P et al. (2013) Statistical inference from multiple iTRAQ experiments without using common reference standards. J Proteome Res 12:594-604

Showing the most recent 10 out of 12 publications