Translational Research Enhancement Core D: Project Summary The DDBTRCC Translational Research Enhancement Core (GI-TREC Core D) has as its goal to make translating basic research findings made by the Core Center Research Base investigators easier and more efficient to achieve. The GI-TREC was established with the understanding that the uniform and standardized harvest of biospecimens with associated, comprehensive clinical, epidemiological and research data would greatly facilitate and improve the study of gastrointestinal physiology and diseases. The two main components of this repository are the Translational/Clinical Research Unit (GI-TREC-T/CRU) to record clinical data and the Tissue Bank (GI-TREC-TxB), which collects, manages, and annotates patient specimens with both research and clinical data. These patient biospecimens include blood, serum, plasma, peripheral blood monocytes, DNA, RNA, urine, stool, and tissue specimens. Combined, these two integrated units provide a cost-effective, efficient centralized tissue banking system to provide high quality, data-associated specimens to multiple users for individual research projects and for fostering collaborations among multiple users. Core D provides the infrastructure for the cost-effective tissue and data collection that meets Best Practices (BPs) through the establishment of uniform Standard Operating Procedures (SOPs) to promote scientific advances by and scientific interactions among Core users, collaborative investigators and young investigators, without each investigator having to invest in the equipment/resources or individually work out specific SOPs. The TREC is aware with bioinformatics resources for translational research being developed and made available by the JHU CTSA and helps instruct our Research Base in its use. The TREC currently holds >40,000 specimens and has been used by 24 current Members, 10 Associate Members and a total of 45 Core Center investigators since the Core Center was funded, and has contributed to 65 publications.

Public Health Relevance

Translational Research Enhancement Core D: Narrative The DDBTRCC Translational Research Enhancement Core (GI-TREC Core D) has as its goal to make translating basic research findings made by the Core Center Research Base easier and more efficient to achieve by investing in a core in which both clinical and research data are recorded and annotated to specimens which are uniformly banked by the Core following strict BPs and SOPs

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK089502-06
Application #
8969783
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2011-06-01
Project End
2021-05-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
6
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Chung, Liam; Thiele Orberg, Erik; Geis, Abby L et al. (2018) Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe 23:203-214.e5
Liu, Liansheng; Zhu, Yaohui; Noë, Michaël et al. (2018) Neuronal Transforming Growth Factor beta Signaling via SMAD3 Contributes to Pain in Animal Models of Chronic Pancreatitis. Gastroenterology 154:2252-2265.e2
Nakamura, Hideki; Lee, Albert A; Afshar, Ali Sobhi et al. (2018) Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions. Nat Mater 17:79-89
Becker, Laren; Nguyen, Linh; Gill, Jaspreet et al. (2018) Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system. Gut 67:827-836
Pierson, Hannah; Muchenditsi, Abigael; Kim, Byung-Eun et al. (2018) The Function of ATPase Copper Transporter ATP7B in Intestine. Gastroenterology 154:168-180.e5
Kim, Sangjune; Yun, Seung Pil; Lee, Saebom et al. (2018) GBA1 deficiency negatively affects physiological ?-synuclein tetramers and related multimers. Proc Natl Acad Sci U S A 115:798-803
Pilla, Scott J; Maruthur, Nisa M; Schweitzer, Michael A et al. (2018) The Role of Laboratory Testing in Differentiating Type 1 Diabetes from Type 2 Diabetes in Patients Undergoing Bariatric Surgery. Obes Surg 28:25-30
Rajkumar, Premraj; Cha, Boyoung; Yin, Jianyi et al. (2018) Identifying the localization and exploring a functional role for Gprc5c in the kidney. FASEB J 32:2046-2059
Pilla, Scott J; Yeh, Hsin-Chieh; Juraschek, Stephen P et al. (2018) Predictors of Insulin Initiation in Patients with Type 2 Diabetes: An Analysis of the Look AHEAD Randomized Trial. J Gen Intern Med 33:839-846
Yin, Jianyi; Tse, Chung-Ming; Avula, Leela Rani et al. (2018) Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. Cell Mol Gastroenterol Hepatol 5:591-609

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