Purpose & Rationale of the Clinical Component of the Administrative Core: Case Western Reserve University (CWRU) School of Medicine is one of the leading research universities in the United States, and currently ranks among the top 25 research institutions in terms of NIH funding. Currently, CWRU is the recipient the Case Comprehensive Cancer Center, one of only 40 NCI-designated comprehensive cancer centers in the United States, and a Clinical and Translational Science Collaborative (CTSC) Award, in collaboration with the Cleveland Clinic Foundation (CCF). The University and its affiliated teaching hospitals have made strong financial commitments to building clinical and translational research through targeted faculty recruitment and resource allocation. Building on these strategic priorities, the Clinical Component of the Cleveland Digestive Diseases Research Core Center (DDRCC) provides access to: 1) reduced rates for DDRCC members to biostatistical consultations, 2) clinical protocol development, and 3) clinical and administrative databases and measurement tools. This DDRCC Clinical Component will greatly facilitate high quality experimental design and analysis, encourage basic research investigators to conduct translational and patient-oriented research studies related to digestive diseases, and facilitate the design and implementation of high-quality clinical studies related to the epidemiology and treatment of digestive disease by physician scientists and clinical investigators alike. The objectives of the Clinical Component are to greatly improve the quality of scientific findings resulting from DDRCC supported projects and to create a conduit for translating basic research into the clinical setting by providing access to experienced biostatisticians and health services and outcomes researchers. The biostatistical services of the proposed Clinical Component will include assistance in preparation of relevant sections of grant proposals and manuscripts, power and sample size calculations, and univariate and multivariate data analysis. The protocol development services will include assistance with approaches to study design, development of appropriate measures including quantitative and qualitative instruments, and access to secondary data sources that are housed at CWRU. These resources will be invaluable to DDRCC members as they translate their research findings from the bench to the bedside.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK097948-05
Application #
9626400
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2019-02-01
Budget End
2020-01-31
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Mehta, Kathan; Jaiswal, Palashkumar; Briggs, Farren et al. (2018) In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study. Sci Rep 8:6825
Liu, Zhonghua; Wang, Chuanping; Rathkey, Joseph K et al. (2018) Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Structure 26:778-784.e3
Cooper, Gregory S; Markowitz, Sanford D; Chen, Zhengyi et al. (2018) Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing. Dig Dis Sci 63:1449-1453
Anderson, Christian E; Wang, Charlie Y; Gu, Yuning et al. (2018) Regularly incremented phase encoding - MR fingerprinting (RIPE-MRF) for enhanced motion artifact suppression in preclinical cartesian MR fingerprinting. Magn Reson Med 79:2176-2182
Perez, Jessica M; Chen, Yinghua; Xiao, Tsan S et al. (2018) Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase. J Biol Chem 293:1100-1105
Petersen, Christine P; Meyer, Anne R; De Salvo, Carlo et al. (2018) A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut 67:805-817
Rodriguez-Palacios, Alexander; Aladyshkina, Natalia; Ezeji, Jessica C et al. (2018) 'Cyclical Bias' in Microbiome Research Revealed by A Portable Germ-Free Housing System Using Nested Isolation. Sci Rep 8:3801
Rieder, F; Bettenworth, D; Ma, C et al. (2018) An expert consensus to standardise definitions, diagnosis and treatment targets for anti-fibrotic stricture therapies in Crohn's disease. Aliment Pharmacol Ther 48:347-357
Chan, M Q; Blum, A E; Chandar, A K et al. (2018) Association of sporadic and familial Barrett's esophagus with breast cancer. Dis Esophagus 31:
Cummings III, Kenneth C; Zimmerman, Nicole M; Maheshwari, Kamal et al. (2018) Epidural compared with non-epidural analgesia and cardiopulmonary complications after colectomy: A retrospective cohort study of 20,880 patients using a national quality database. J Clin Anesth 47:12-18

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