Center overview abstract The Stanford Diabetes Research Center (SDRC) embodies the culmination of a long-term strategic plan by the Stanford University School of Medicine to create a premier program founded on a base of superb, collaborative investigators studying basic, clinical and translational problems focused on improving diabetes care. Support of this P30 application will leverage diabetes research at Stanford University by providing key resources dedicated to supporting research, training and clinical activities focused on diabetes. Stanford has a well- known tradition and reputation for academic excellence, scientific innovation, and clinical care, united in a true University located on a single campus that facilitates and encourages interaction between scientists and clinicians from different disciplines. Stanford is the heart of Silicon Valley, an epicenter of innovation and calculated risk-taking, whose technology companies, start-ups, and mobile health companies partner with SDRC faculty in unique and growing collaborations to advance diabetes research and care. The SDRC is comprised of 94 investigators in 23 departments from the Schools of Medicine, Engineering, and Humanities & Sciences. The SDRC mission is to foster innovation, new knowledge, and training in basic and translational diabetes-related research, leading to improved diagnosis, treatment and prevention of diabetes and its complications. The SDRC consists of: 1) Administrative Component that coordinates the scientific, organizational, and outreach activities; 2) Biomedical Research Component that recruits and selects SDRC- affiliated investigators and supervises the research cores that facilitate and enhance their research; 3) Pilot and Feasibility Program that facilitates the development of new investigators into independent scientists and encourages scientists in other fields to enter the field of diabetes research; and 4) Enrichment, Training, and Outreach Program that fosters an environment conducive to collaborative, interdisciplinary research on diabetes. NIH support for the SDRC is greatly amplified by: 1) Stanford's sustained commitment to provide research space and additional financial resources; 2) a diverse, comprehensive array of research core services at Stanford, which allows NIH funds to support unique, diabetes-related research cores; and 3) collaborative efforts with other NIH-funded research centers at Stanford. The SDRC is evolving and dynamic, including additions to its investigator base and research areas, expanded focus on clinical and translational research, and evolution of core support to provide unique, indispensable core services devoted to diabetes research. Because of the strategic plan to create a strong Stanford Diabetes Research Center, and the culture of innovation this Center at Stanford creates, SCRC-affiliated investigators have made and are poised to continue making important scientific contributions related to diabetes, obesity, and metabolism.

Public Health Relevance

Project_Narrative: Overall This P30 application from the Stanford Diabetes Research Center (SDRC) seeks support for its efforts to discover, apply and translate science about diabetes and it complications, with the goal of improving health by reducing the burden of diabetes. The SDRC is founded on a base of superb, collaborative investigators studying basic, clinical and translational problems in diabetes at Stanford University, which has a tradition and reputation for scientific innovation and clinical care, located in the heart of Silicon Valley, an epicenter of transformative discovery and calculated risk-taking. Support of this P30 application will leverage diabetes research at Stanford University by providing key resources to support Research Cores, and a Pilot and Feasibility Award Program to foster innovative diabetes research, and Enrichment Programs focused on diabetes research, education and care.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK116074-02
Application #
9565579
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Hyde, James F
Project Start
2017-09-15
Project End
2022-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Stanford University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304
Fall, Tove; Gustafsson, Stefan; Orho-Melander, Marju et al. (2018) Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank. Diabetologia :
Nagy, Nadine; de la Zerda, Adi; Kaber, Gernot et al. (2018) Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem 293:567-578
Rao, Abhiram S; Lindholm, Daniel; Rivas, Manuel A et al. (2018) Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke. Circ Genom Precis Med 11:e002162
Shen, Wen-Jun; Asthana, Shailendra; Kraemer, Fredric B et al. (2018) Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function. J Lipid Res 59:1114-1131
Nowak, Christoph; Hetty, Susanne; Salihovic, Samira et al. (2018) Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance. Sci Rep 8:8691
Bahrami-Nejad, Zahra; Zhao, Michael L; Tholen, Stefan et al. (2018) A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation. Cell Metab 27:854-868.e8
Piening, Brian D; Zhou, Wenyu; Contrepois, Kévin et al. (2018) Integrative Personal Omics Profiles during Periods of Weight Gain and Loss. Cell Syst 6:157-170.e8
Kamble, Prasad G; Pereira, Maria J; Gustafsson, Stefan et al. (2018) Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover. Adipocyte 7:285-296
LeBlanc, Erin S; Pratley, Richard E; Dawson-Hughes, Bess et al. (2018) Baseline Characteristics of the Vitamin D and Type 2 Diabetes (D2d) Study: A Contemporary Prediabetes Cohort That Will Inform Diabetes Prevention Efforts. Diabetes Care 41:1590-1599
Tikkanen, Emmi; Gustafsson, Stefan; Amar, David et al. (2018) Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank. Sci Rep 8:6451

Showing the most recent 10 out of 46 publications