PILOT PROJECT PROGRAM Director: Moon-shong (Eric) Tang, Ph.D. SIGNIFICANCE The four specific aims of this Pilot Project Program (PPP) are to: 1) promote the long-range research interests of the Center;2) foster collaboration between Center members and the NYU community;3) encourage Center investigators to explore new research initiatives;and 4) assist promising new investigators in establishing independent research in environmental health sciences. We have been very successful at achieving these four goals for the past ten years. The following are a few highlights of our successes in achieving these specific aims during the past five years. As one of the goals of this Center, efforts to understand the mechanisms of action, component composition, adverse health effects, mitigation and risks of ambient air exposures have been supported by a long and outstanding history in inhalation toxicology research. The PPP has worked diligently with Center faculty in achieving these goals. PPP funding has supported the establishment of a novel organ bath system that allowed for novel collaborative research conducted by Drs. L.-C. Chen and Lippmann in the assessment of the vascular function of aorta rings and small arteries. We have also provided PPP funding for the development of a new method of inhalation exposure: a

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES000260-48A1
Application #
8279597
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1997-04-01
Project End
2017-03-31
Budget Start
2012-04-27
Budget End
2013-03-31
Support Year
48
Fiscal Year
2012
Total Cost
$229,464
Indirect Cost
$86,049
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Brocato, Jason; Costa, Max (2015) 10th NTES Conference: Nickel and arsenic compounds alter the epigenome of peripheral blood mononuclear cells. J Trace Elem Med Biol 31:209-13
Arslan, Alan A; Koenig, Karen L; Lenner, Per et al. (2014) Circulating estrogen metabolites and risk of breast cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev 23:1290-7
Zhang, Dongyun; Wang, Yulei; Liang, Yuguang et al. (2014) Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration. J Cell Sci 127:2920-33
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Zhou, Ming; Shao, Yongzhao (2014) A Powerful Test for Multivariate Normality. J Appl Stat 41:351-363
Yao, Yixin; Lu, Yinghua; Chen, Wen-Chi et al. (2014) Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination. PLoS One 9:e86620
Fang, Lei; Wuptra, Kenly; Chen, Danqi et al. (2014) Environmental-stress-induced Chromatin Regulation and its Heritability. J Carcinog Mutagen 5:
Liberda, Eric N; Cuevas, Azita K; Qu, Qingshan et al. (2014) The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells. Inhal Toxicol 26:588-97
Yao, Yixin; Dai, Wei (2014) Genomic Instability and Cancer. J Carcinog Mutagen 5:
Wu, Fen; Jasmine, Farzana; Kibriya, Muhammad G et al. (2014) Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh. Toxicol Appl Pharmacol 276:195-203

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