PILOT PROJECT PROGRAM Director: Moon-shong (Eric) Tang, Ph.D. SIGNIFICANCE The four specific aims of this Pilot Project Program (PPP) are to: 1) promote the long-range research interests of the Center;2) foster collaboration between Center members and the NYU community;3) encourage Center investigators to explore new research initiatives;and 4) assist promising new investigators in establishing independent research in environmental health sciences. We have been very successful at achieving these four goals for the past ten years. The following are a few highlights of our successes in achieving these specific aims during the past five years. As one of the goals of this Center, efforts to understand the mechanisms of action, component composition, adverse health effects, mitigation and risks of ambient air exposures have been supported by a long and outstanding history in inhalation toxicology research. The PPP has worked diligently with Center faculty in achieving these goals. PPP funding has supported the establishment of a novel organ bath system that allowed for novel collaborative research conducted by Drs. L.-C. Chen and Lippmann in the assessment of the vascular function of aorta rings and small arteries. We have also provided PPP funding for the development of a new method of inhalation exposure: a

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES000260-48A1
Application #
8279597
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1997-04-01
Project End
2017-03-31
Budget Start
2012-04-27
Budget End
2013-03-31
Support Year
48
Fiscal Year
2012
Total Cost
$229,464
Indirect Cost
$86,049
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Blum, Jason L; Chen, Lung-Chi; Zelikoff, Judith T (2017) Exposure to Ambient Particulate Matter during Specific Gestational Periods Produces Adverse Obstetric Consequences in Mice. Environ Health Perspect 125:077020
Yinon, Lital; Thurston, George (2017) An evaluation of the health benefits achieved at the time of an air quality intervention in three Israeli cities. Environ Int 102:66-73
Jagannathan, Lakshmanan; Jose, Cynthia C; Tanwar, Vinay Singh et al. (2017) Identification of a unique gene expression signature in mercury and 2,3,7,8-tetrachlorodibenzo-p-dioxin co-exposed cells. Toxicol Res (Camb) 6:312-323
Church, Jamie S; Tijerina, Pamella B; Emerson, Felicity J et al. (2017) Perinatal exposure to concentrated ambient particulates results in autism-like behavioral deficits in adult mice. Neurotoxicology :
Gany, Francesca; Bari, Sehrish; Prasad, Lakshmi et al. (2017) Perception and reality of particulate matter exposure in New York City taxi drivers. J Expo Sci Environ Epidemiol 27:221-226
Huang, Haishan; Jin, Honglei; Zhao, Huirong et al. (2017) RhoGDI? promotes Sp1/MMP-2 expression and bladder cancer invasion through perturbing miR-200c-targeted JNK2 protein translation. Mol Oncol 11:1579-1594
Jerrett, Michael; Turner, Michelle C; Beckerman, Bernardo S et al. (2017) Comparing the Health Effects of Ambient Particulate Matter Estimated Using Ground-Based versus Remote Sensing Exposure Estimates. Environ Health Perspect 125:552-559
Zhou, C; Huang, C; Wang, J et al. (2017) LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1? translation. Oncogene 36:3878-3889
Klocke, Carolyn; Allen, Joshua L; Sobolewski, Marissa et al. (2017) Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination. Neurotoxicology :
Howe, Caitlin G; Liu, Xinhua; Hall, Megan N et al. (2017) Sex-Specific Associations between One-Carbon Metabolism Indices and Posttranslational Histone Modifications in Arsenic-Exposed Bangladeshi Adults. Cancer Epidemiol Biomarkers Prev 26:261-269

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