PILOT PROJECT PROGRAM Director: Moon-shong (Eric) Tang, Ph.D. SIGNIFICANCE The four specific aims of this Pilot Project Program (PPP) are to: 1) promote the long-range research interests of the Center;2) foster collaboration between Center members and the NYU community;3) encourage Center investigators to explore new research initiatives;and 4) assist promising new investigators in establishing independent research in environmental health sciences. We have been very successful at achieving these four goals for the past ten years. The following are a few highlights of our successes in achieving these specific aims during the past five years. As one of the goals of this Center, efforts to understand the mechanisms of action, component composition, adverse health effects, mitigation and risks of ambient air exposures have been supported by a long and outstanding history in inhalation toxicology research. The PPP has worked diligently with Center faculty in achieving these goals. PPP funding has supported the establishment of a novel organ bath system that allowed for novel collaborative research conducted by Drs. L.-C. Chen and Lippmann in the assessment of the vascular function of aorta rings and small arteries. We have also provided PPP funding for the development of a new method of inhalation exposure: a "fishing line" system, that permits very small quantities of atmospheric particles to be used for nose-only exposure regimens. The novelty of this concept, the preliminary results generated by the collaborative work of Drs. Cohen and L.-C. Chen, along with the track record of these two researchers in collecting and studying World Trade Center (WTC) dust, have resulted in more than $2 million dollars of support from CDC/NIOSH to fund further research with WTC dust. We have supported Dr. Lippmann in determining the seasonal, regional, and local contributions to particulate matter (PM) composition in the New York City area, which is complemented by Drs. L.-C. Chen and Qu's study of the effects of PM composition on blood vessel damage and repair. The approaches, substantial results and the experimental designs supported and pioneered by these pilot research collaborations have reinforced the strengths of these investigators and laid a strong foundation, for the establishment of EPA and HEl funded PM Centers. In addition, the Center has a tradition of being a leader in understanding the molecular mechanisms of metal toxicity and carcinogenicity. The PPP has encouraged both classic epidemiological toxicology approaches and cutting edge molecular approaches to understanding the genetic and epigenetic roles in metal toxicity and carcinogenicity. The PPP supported Dr. Qu's research in identifying a variety of biomarkers that could be useful In large-scale epidemiological studies as markers for risk assessment in humans exposed to Cr(VI) at low ambient levels. The PPP also funded a new venture by Drs. Dai and Rossman in the determination of the effects of arsenic on the cell cycle and chromosomal stability. Also, we have supported two projects with multiple Pi's in the pursuit of understanding the effects of metals on epigenetics. In one pilot project, Drs. Wirgin, Costa, and Roy investigated the in vivo epigenetic effects of chromium, nickel, and arsenic exposure on histone marks in the early life-stages of fish. In another project, Drs. Costa and Qu examined, using ChlP-Seq, the long- and short-term effects of nickel exposure on gene expression by examining changes in H3K4 trimethylation and H3K9 dimethylafion throughout the human genome.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000260-50
Application #
8651455
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
50
Fiscal Year
2014
Total Cost
$229,464
Indirect Cost
$86,049
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Brocato, Jason; Costa, Max (2015) 10th NTES Conference: Nickel and arsenic compounds alter the epigenome of peripheral blood mononuclear cells. J Trace Elem Med Biol 31:209-13
Arslan, Alan A; Koenig, Karen L; Lenner, Per et al. (2014) Circulating estrogen metabolites and risk of breast cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev 23:1290-7
Zhang, Dongyun; Wang, Yulei; Liang, Yuguang et al. (2014) Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration. J Cell Sci 127:2920-33
Chen, Yu; Ge, Wenzhen; Parvez, Faruque et al. (2014) A prospective study of arm circumference and risk of death in Bangladesh. Int J Epidemiol 43:1187-96
Zhou, Ming; Shao, Yongzhao (2014) A Powerful Test for Multivariate Normality. J Appl Stat 41:351-363
Yao, Yixin; Lu, Yinghua; Chen, Wen-Chi et al. (2014) Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination. PLoS One 9:e86620
Fang, Lei; Wuptra, Kenly; Chen, Danqi et al. (2014) Environmental-stress-induced Chromatin Regulation and its Heritability. J Carcinog Mutagen 5:
Liberda, Eric N; Cuevas, Azita K; Qu, Qingshan et al. (2014) The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells. Inhal Toxicol 26:588-97
Yao, Yixin; Dai, Wei (2014) Genomic Instability and Cancer. J Carcinog Mutagen 5:
Wu, Fen; Jasmine, Farzana; Kibriya, Muhammad G et al. (2014) Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh. Toxicol Appl Pharmacol 276:195-203

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