The overall goal of the IHSFC is to facilitate both patient-oriented and population-based research directed at studies of the etiology, pathogenesis, and prognosis of disease in patient populations, and to integrate this work with the strong basic science programs within the Center in Molecular Toxicology.
Aim 1. To stimulate and support both clinical and translational research, including patient-oriented and population-based research, within the Vanderbilt P30 EHS Core Center by expanding existing research projects and fostering new interdisciplinary activities focusing on environmental health problems.
Aim 2. To describe the development process, infrastructure and outcomes of the IHFSC in order to not only create, but optimize and be a successful example of developing a core infrastructure and environment for interdisciplinary science both for the purposes of conducting interdisciplinary research, as well as for training new interdisciplinary scientists both among the ranks of established investigators, as well as among trainees.
|Aboud, Asad A; Tidball, Andrew M; Kumar, Kevin K et al. (2015) PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Neurobiol Dis 73:204-12|
|Davies, Sean S; Guo, Lilu (2014) Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids. Chem Phys Lipids 181:1-33|
|Mullins, Elwood A; Rubinson, Emily H; Eichman, Brandt F (2014) The substrate binding interface of alkylpurine DNA glycosylase AlkD. DNA Repair (Amst) 13:50-4|
|Stavros, Kallie M; Hawkins, Edward K; Rizzo, Carmelo J et al. (2014) Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence. Nucleic Acids Res 42:3450-63|
|Ehrmann, David C; Rose, Kristie; Calcutt, M Wade et al. (2014) Glutathionylated ?G and ?A subunits of hemoglobin F: a novel post-translational modification found in extremely premature infants by LC-MS and nanoLC-MS/MS. J Mass Spectrom 49:178-83|
|Liu, Wei; Xu, Libin; Lamberson, Connor et al. (2014) A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. J Lipid Res 55:329-37|
|Bowman, Aaron B; Aschner, Michael (2014) Considerations on manganese (Mn) treatments for in vitro studies. Neurotoxicology 41:141-2|
|Brinkhaus, Sigrid Grosse; Bornhorst, Julia; Chakraborty, Sudipta et al. (2014) Elemental bioimaging of manganese uptake in C. elegans. Metallomics 6:617-21|
|Lamberson, Connor R; Xu, Libin; Muchalski, Hubert et al. (2014) Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations. J Am Chem Soc 136:838-41|
|Petrova, Katya V; Millsap, Amy D; Stec, Donald F et al. (2014) Characterization of the deoxyguanosine-lysine cross-link of methylglyoxal. Chem Res Toxicol 27:1019-29|
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