The Administrative Core is responsible for coordinating P30 EHS Core Center activities, including the integration of all Center components, management of day-to-day operations, program assessment, and various clerical and accounting functions. The Center in Molecular Toxicology has recently expanded into a more comprehensive organization that administers several units under a common "umbrella," as part of the new 5-year strategic plan distributed in 2006 by Vanderbilt's Associate Vice-Chancellor for Research (and current Dean of the School of Medicine), Dr J. Balser. Historically, the Center consisted of two major programs: the P30 EHS Core Center grant (this application, P30 ES000267) and the affiliated training program in environmental toxicology (T32 ES007028). Today the P30 EHS Core Center and training programs continue to provide much of the research and training infrastructure for the Center in Molecular Toxicology, but several other programs and initiatives are now included under the Center's administrative umbrella: ? Advanced Research Cooperation in Environmental Health (ARCH) with Meharry Medical College (S11 ES014156) Manganese Health Research Program (funded by the Department of Defense) ? Patient-Oriented Career Development Program (K12 ES015855), which provides support for environmental health science scholars (described in further detail, pp. 146-151) ? A newly funded NIEHS T35 short-term summer research and training program for medical students (T35 ES016534-01) ? An NIEHS Superfund Basic Research Program with Oak Ridge National Laboratory focusing on mechanisms of susceptibility to mercury toxicity (submitted 04/08). The priority score from this round was not competitive for funding, and a resubmission is planned for 04/10. ? A proposed institutionally-sponsored program in mechanisms of drug-induced cellular toxicity Thus the Administrative Core has been instrumental in leveraging resources with the goal of amplifying Vanderbilt's presence in the field of environmental toxicology as it relates to human health.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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Vanderbilt University Medical Center
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Aboud, Asad A; Tidball, Andrew M; Kumar, Kevin K et al. (2015) PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Neurobiol Dis 73:204-12
Davies, Sean S; Guo, Lilu (2014) Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids. Chem Phys Lipids 181:1-33
Mullins, Elwood A; Rubinson, Emily H; Eichman, Brandt F (2014) The substrate binding interface of alkylpurine DNA glycosylase AlkD. DNA Repair (Amst) 13:50-4
Stavros, Kallie M; Hawkins, Edward K; Rizzo, Carmelo J et al. (2014) Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence. Nucleic Acids Res 42:3450-63
Ehrmann, David C; Rose, Kristie; Calcutt, M Wade et al. (2014) Glutathionylated ?G and ?A subunits of hemoglobin F: a novel post-translational modification found in extremely premature infants by LC-MS and nanoLC-MS/MS. J Mass Spectrom 49:178-83
Liu, Wei; Xu, Libin; Lamberson, Connor et al. (2014) A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. J Lipid Res 55:329-37
Bowman, Aaron B; Aschner, Michael (2014) Considerations on manganese (Mn) treatments for in vitro studies. Neurotoxicology 41:141-2
Brinkhaus, Sigrid Grosse; Bornhorst, Julia; Chakraborty, Sudipta et al. (2014) Elemental bioimaging of manganese uptake in C. elegans. Metallomics 6:617-21
Lamberson, Connor R; Xu, Libin; Muchalski, Hubert et al. (2014) Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations. J Am Chem Soc 136:838-41
Petrova, Katya V; Millsap, Amy D; Stec, Donald F et al. (2014) Characterization of the deoxyguanosine-lysine cross-link of methylglyoxal. Chem Res Toxicol 27:1019-29

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