B. ENVIRONMENTAL HEALTH IDENTITY AND IMPACT OF RESEARCH BASE B.I. HISTORY OF ENVIRONMENTAL HEALTH SCIENCES AT THE UNIVERSITY OF ROCHESTER Research supported by the Manhattan Project in the 1940s initiated toxicology programs at the University of Rochester. Teams of scientists from different disciplines were assembled in Rochester to determine health effects of uranium, fluorides, mercury and other agents used in the process of nuclear weapons production. These endeavors focused on identifying routes of human exposure, defining mechanisms by which these elements would impair function, assessing vulnerability at different life stages, and developing approaches that could ameliorate toxicant burdens in target tissues. What emerged was an international resource in the toxicology of metals and inorganic elements that remains one of the strengths of the EHSC today.

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Reilly, Emma C; Martin, Kyle C; Jin, Guang-bi et al. (2015) Neonatal hyperoxia leads to persistent alterations in NK responses to influenza A virus infection. Am J Physiol Lung Cell Mol Physiol 308:L76-85
Rand, Matthew D (2014) A method of permeabilization of Drosophila embryos for assays of small molecule activity. J Vis Exp :
Gardner, Blake; Ling, Frederick; Hopke, Philip K et al. (2014) Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study. Part Fibre Toxicol 11:1
Oller, Adriana R; Oberd√∂rster, G√ľnter; Seilkop, Steven K (2014) Derivation of PM10 size-selected human equivalent concentrations of inhaled nickel based on cancer and non-cancer effects on the respiratory tract. Inhal Toxicol 26:559-78
Montgomery, Sara L; Vorojeikina, Daria; Huang, Wen et al. (2014) Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways. PLoS One 9:e110375
Wheeler, Jennifer L H; Martin, Kyle C; Resseguie, Emily et al. (2014) Differential consequences of two distinct AhR ligands on innate and adaptive immune responses to influenza A virus. Toxicol Sci 137:324-34
Orlando, Mark S; Dziorny, Adam C; Harrington, Donald et al. (2014) Associations between prenatal and recent postnatal methylmercury exposure and auditory function at age 19 years in the Seychelles Child Development Study. Neurotoxicol Teratol 46:68-76
Sundar, Isaac K; Nevid, Michael Z; Friedman, Alan E et al. (2014) Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer. J Proteome Res 13:982-96
Prince, Lisa; Korbas, Malgorzata; Davidson, Philip et al. (2014) Target organ specific activity of drosophila MRP (ABCC1) moderates developmental toxicity of methylmercury. Toxicol Sci 140:425-35
Regal, Jean F; Lawrence, B Paige; Johnson, Alex C et al. (2014) Neonatal oxygen exposure alters airway hyper-responsiveness but not the response to allergen challenge in adult mice. Pediatr Allergy Immunol 25:180-6

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