Abstract

B. ENVIRONMENTAL HEALTH IDENTITY AND IMPACT OF RESEARCH BASE B.I. HISTORY OF ENVIRONMENTAL HEALTH SCIENCES AT THE UNIVERSITY OF ROCHESTER Research supported by the Manhattan Project in the 1940s initiated toxicology programs at the University of Rochester. Teams of scientists from different disciplines were assembled in Rochester to determine health effects of uranium, fluorides, mercury and other agents used in the process of nuclear weapons production. These endeavors focused on identifying routes of human exposure, defining mechanisms by which these elements would impair function, assessing vulnerability at different life stages, and developing approaches that could ameliorate toxicant burdens in target tissues. What emerged was an international resource in the toxicology of metals and inorganic elements that remains one of the strengths of the EHSC today.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001247-40
Application #
8651465
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
40
Fiscal Year
2014
Total Cost
$385,543
Indirect Cost
$136,001

  Institution

Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Wong, Elissa L; Lutz, Nina M; Hogan, Victoria A et al. (2018) Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex. Brain Behav Immun 67:257-278
Barrett, Emily S; Vitek, Wendy; Mbowe, Omar et al. (2018) Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Hum Reprod 33:1757-1766
Franchini, Anthony M; Lawrence, B Paige (2018) Environmental exposures are hidden modifiers of anti-viral immunity. Curr Opin Toxicol 10:54-59
van den Dries, Michiel A; Pronk, Anjoeka; Guxens, Mònica et al. (2018) Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands. Int J Hyg Environ Health 221:489-501
Beach, Tyler A; Groves, Angela M; Johnston, Carl J et al. (2018) Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis. Int J Radiat Biol 94:1104-1115
Morris-Schaffer, Keith; Sobolewski, Marissa; Welle, Kevin et al. (2018) Cognitive flexibility deficits in male mice exposed to neonatal hyperoxia followed by concentrated ambient ultrafine particles. Neurotoxicol Teratol 70:51-59
Santos, Susana; Eekhout, Iris; Voerman, Ellis et al. (2018) Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. BMC Med 16:201
Huang, Li-Shan; Cory-Slechta, Deborah A; Cox, Christopher et al. (2018) Analysis of Nonlinear Associations between Prenatal Methylmercury Exposure from Fish Consumption and Neurodevelopmental Outcomes in the Seychelles Main Cohort at 17 Years. Stoch Environ Res Risk Assess 32:893-904
Leonard, Antony; Rahman, Arshad; Fazal, Fabeha (2018) Importins ? and ? signaling mediates endothelial cell inflammation and barrier disruption. Cell Signal 44:103-117
Prince, Lisa M; Rand, Matthew D (2018) Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation. Toxicology 393:113-122

Showing the most recent 10 out of 556 publications