The overarching goal of the CEHS Integrative Health Sciences Facilities Core (IHSFC) is to facilitate the translation of CEHS members'basic research findings into clinical or public health applications. In the context of a research Institution that is not affiliated with a Medical School or a School of Public Health, the MIT CEHS contributes to the diversity of the NIEHS Core Centers Program with major strengths in fundamental science and engineering applied to problems in EHS and toxicology. The past decade has seen an evolution in CEHS research activities toward translational research, based on the pioneering studies of aflatoxin-induced liver cancer conducted by Gerald Wogan and coworkers in the CEHS. This evolution is evident in the intentional expansion of Center membership to embrace the state-of-the-art molecular epidemiological studies of David Hunter and Jiali Han at the Harvard School of Public Health and the Harvard Medical School, the emergence of human studies in the Molecular Biomarkers for Environmental Toxicants Program with Gerald Wogan, Steven Tannenbaum and others at Johns Hopkins University, and James Fox's studies of human cancer risk from environmental microbes in South America and Southeast Asia, just to mention a few. The CEHS leadership has now capitalized on this translational momentum with the creation of the CEHS IHSFC. It is important at the outset to define """"""""translation"""""""" in the context of the MIT CEHS. The activities that constitute translational research in environmental health science fall along a continuum, such as that shown below and adapted from a diagram prepared by Dr. Samuel Wilson of the NIEHS. The NIEHS defines translational research as, """"""""efforts along the spectrum of steps that transform scientific discoveries arising from laboratory, clinical, or population studies into clinical or population-based applications to reduce disease incidence, morbidity, and mortality."""""""" For the MIT CEHS, the steps in translation move research along the spectrum from molecules, pathways and networks, toward cells, tissues and organs, and ultimately moving all the way to whole organisms (mice or human) and to human populations. Each move to the right in the adjacent figure represents translational research. The historical experience of CEHS members reveals that the greatest hurdles to engaging in translational science are a lack of awareness of translational resources and the """"""""activation energy"""""""" needed to engage in translational research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES002109-34
Application #
8650830
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
34
Fiscal Year
2014
Total Cost
$51,036
Indirect Cost
$17,945
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Mannion, Anthony; Shen, Zeli; Feng, Yan et al. (2016) Draft Genome Sequences of Five Novel Polyketide Synthetase-Containing Mouse Escherichia coli Strains. Genome Announc 4:
Shabab, Mohammed; Arnold, Markus F F; Penterman, Jon et al. (2016) Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247. Proc Natl Acad Sci U S A 113:10157-62
Milani, Pamela; Escalante-Chong, Renan; Shelley, Brandon C et al. (2016) Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells. Sci Rep 6:25474
Din, M Omar; Danino, Tal; Prindle, Arthur et al. (2016) Synchronized cycles of bacterial lysis for in vivo delivery. Nature 536:81-5
Yu, Amy Marie; Calvo, Jennifer A; Muthupalani, Suresh et al. (2016) The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury. Oncotarget 7:28624-36
Manley, Leigh J; Ma, Duanduan; Levine, Stuart S (2016) Monitoring Error Rates In Illumina Sequencing. J Biomol Tech 27:125-128
Woods, Stephanie E; Ek, Courtney; Shen, Zeli et al. (2016) Male Syrian Hamsters Experimentally Infected with Helicobacter spp. of the H. bilis Cluster Develop MALT-Associated Gastrointestinal Lymphomas. Helicobacter 21:201-17
Spencer, Sarah J; Tamminen, Manu V; Preheim, Sarah P et al. (2016) Massively parallel sequencing of single cells by epicPCR links functional genes with phylogenetic markers. ISME J 10:427-36
Mackos, A R; Galley, J D; Eubank, T D et al. (2016) Social stress-enhanced severity of Citrobacter rodentium-induced colitis is CCL2-dependent and attenuated by probiotic Lactobacillus reuteri. Mucosal Immunol 9:515-26
Zimanyi, Christina M; Chen, Percival Yang-Ting; Kang, Gyunghoon et al. (2016) Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife 5:e07141

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