This is a renewal application for the Johns Hopkins Center in Urban Environmental Health for the five-year period April 2008 to March 2013.The long-term goals emanating from the theme of our Center are (a) to identify environmental exposures, their biological consequences and underlying susceptibility factors, the nexus of gene-environment interactions, that alone or together increase health risk for people living in urban environments, such as Baltimore, and (b) to use these findings to develop prevention and intervention strategies to improve urban environmental health both locally and globally. The Center is organized with three research foci under the leadership of Dr. Jonathan Samet (Research Focus 1: Environmental Epidemiology and Exposure Assessment), Dr. Valeria Culotta (Research Focus 2: Molecular Basis of Environmental Disease) and Dr. Paul Strickland (Research Focus 3: Public Health Interventions and Prevention). Each of these leaders have been in similar leadership positions in this Center for the past ten years and therefore there will be continuity in the transition to this new Center structure. The Community Outreach and Education Core is being maintained under the leadership of Dr. Michale Trush. The implementation of the Integrative Health Sciences Facility Core has been accomplished and the other facility core is Bioinformatics and Biostatistics. The management of the Center is facilitated by using both an Internal and External Advisory Board structure. The Center's Pilot Project Program is essential to meet our goal's and these resources provide seed funding of new ideas which can result in the generation of preliminary data in support of a subsequent grant application. The Directors Fund has been established and these monies will primarily be used for the rapid response to opportunities that emerge from the Integrated Health Sciences Facility Core. In summary, we feel that our strategies over the next five years will continue to help us address the long-term goals emanating from the theme of our Center: to identify environmental exposures, their consequences and underlying susceptibility factors, the nexus of gene-environment interactions, that alone or together increase health risk for people living in urban environments, such as Baltimore, and then to use these findings to develop prevention and intervention strategies to improve global environmental health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES003819-25
Application #
8248223
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
1985-09-27
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
25
Fiscal Year
2012
Total Cost
$1,766,847
Indirect Cost
$866,151
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Kim, Jung-Hyun; Thimmulappa, Rajesh K; Kumar, Vineet et al. (2014) NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest 124:730-41
Kaji, Deepak A; Belli, Andrew J; McCormack, Meredith C et al. (2014) Indoor pollutant exposure is associated with heightened respiratory symptoms in atopic compared to non-atopic individuals with COPD. BMC Pulm Med 14:147
Penning, Trevor M; Breysse, Patrick N; Gray, Kathleen et al. (2014) Environmental health research recommendations from the Inter-Environmental Health Sciences Core Center Working Group on unconventional natural gas drilling operations. Environ Health Perspect 122:1155-9
Pollard, Suzanne L; Williams, D'Ann L; Breysse, Patrick N et al. (2014) A cross-sectional study of determinants of indoor environmental exposures in households with and without chronic exposure to biomass fuel smoke. Environ Health 13:21
Johnson, Natalie M; Egner, Patricia A; Baxter, Victoria K et al. (2014) Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold. Cancer Prev Res (Phila) 7:658-65
Egner, Patricia A; Chen, Jian-Guo; Zarth, Adam T et al. (2014) Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila) 7:813-23
Zheng, Laura; Kuo, Chin-Chi; Fadrowski, Jeffrey et al. (2014) Arsenic and Chronic Kidney Disease: A Systematic Review. Curr Environ Health Rep 1:192-207
Wasserman, Gail A; Liu, Xinhua; Loiacono, Nancy J et al. (2014) A cross-sectional study of well water arsenic and child IQ in Maine schoolchildren. Environ Health 13:23
Tellez-Plaza, Maria; Tang, Wan-Yee; Shang, Yan et al. (2014) Association of global DNA methylation and global DNA hydroxymethylation with metals and other exposures in human blood DNA samples. Environ Health Perspect 122:946-54
Gribble, Matthew O; Tang, Wan-Yee; Shang, Yan et al. (2014) Differential methylation of the arsenic (III) methyltransferase promoter according to arsenic exposure. Arch Toxicol 88:275-82

Showing the most recent 10 out of 284 publications