The mission of the Center for Environmental Exposure and Disease (CEED) is to improve human health by performing transdisciplinary research to elucidate how the total environment, the genome and the epigenome interact to mitigate the risk of disease. CEED research focuses on: 1) assessing and modeling exposures, 2) discovering and applying biological response indicators which link exposures to mechanisms of pathogenesis, 3) developing and implementing targeted prevention, intervention, and treatment strategies, 4) reducing exposures by influencing public policy, planning and regulation, and 5) engaging and informing stakeholders. By analogy with Precision Medicine, CEED envisions that the integration of data from exposure biology, genomics, epigenetics and microbiomics to assess exposures, biological responses, mechanisms of pathogenesis and disease prevention will significantly impact the future of environmental health. The CEED vision is to lead the development of precision environmental health research through the integration of clinical, basic, and population-based studies, using the acquired information to prevent and/or treat environmental disease. The strategy is to combine the Center's long-standing breadth and depth of expertise in environmental health research with new capabilities in exposure biology, epigenomics, and microbiomics.
The Specific Aims are:
Aim 1 : Move basic, clinical and population research toward precision environmental health by: i) fostering a collaborative, transdisciplinary research environment, ii) supporting innovative research and emerging science through Pilot grant funding, and iii) providing cost-effective access to Facility Cores that maintain state-of-the-art technologies and expertise.
Aim 2 : Provide training and mentoring opportunities to junior investigators and established researchers in innovative and emerging environmental health research through: i) mentoring committees and a structured mentoring curriculum, ii) collaborative research, iii) Career Development Awards and Pilot Project grants, and iv) opportunities for expanded training with other NIEHS Centers.
Aim 3 : Strengthen and expand existing relationships with community partners by: i) facilitating bidirectional interactions among CEED researchers and community partners to identify environmental concerns and desired outcomes, ii) developing research programs that address community health needs, and iii) providing research results, educational materials and expertise to communities and health professionals, enabling them to minimize exposures and influence public health policy.
Aim 4 : Translate research findings to stakeholders in local, state and federal government agencies to provide guidance on mitigation of risk, to influence public policy, and to support legislation that reduces exposure and improve environmental health.

Public Health Relevance

The mission of the CEED is to improve human health by performing transdisciplinary research to elucidate how the total environment interacts with host factors to mitigate the risk of disease. To accomplish the mission, CEED researchers focuses on: 1) assessing and modeling exposures;2) discovering and applying biological response indicators which link exposures to mechanisms of pathogenesis;3) developing and implementing targeted prevention, intervention, and treatment strategies;4) reducing exposures by influencing public policy, planning and regulation;and 5) engaging and informing stakeholders. CEED envisions that the integration of data from exposure biology, genomics, epigenetics and microbiomics to assess exposures, biological responses, mechanisms of pathogenesis and disease prevention, will significantly impact the future of environmental health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES005022-27
Application #
8622105
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2014-07-29
Budget End
2015-03-31
Support Year
27
Fiscal Year
2014
Total Cost
$159,000
Indirect Cost
$59,000
Name
Rbhs-Robert Wood Johnson Medical School
Department
Type
DUNS #
078795875
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
Mamounis, Kyle J; Hernandez, Michelle R; Margolies, Nicholas et al. (2018) Interaction of 17?-estradiol and dietary fatty acids on energy and glucose homeostasis in female mice. Nutr Neurosci 21:715-728
Graber, Judith M; Chuang, Connie T; Ward, Carolyn L et al. (2018) Head and Neck Cancer in World Trade Center Responders: A Case Series. J Occup Environ Med 60:e439-e444
Stapleton, P A; McBride, C R; Yi, J et al. (2018) Estrous cycle-dependent modulation of in vivo microvascular dysfunction after nanomaterial inhalation. Reprod Toxicol 78:20-28
Dai, Zhuqing; Feng, Simin; Liu, Anna et al. (2018) Anti-inflammatory effects of newly synthesized ?-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice. Food Res Int 109:350-357
Graber, Judith M; Alexander, Cora; Laumbach, Robert J et al. (2018) Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013-2014 NHANES. J Expo Sci Environ Epidemiol :
Feng, Simin; Dai, Zhuqing; Liu, Anna B et al. (2018) Intake of stigmasterol and ?-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet. Biochim Biophys Acta Mol Cell Biol Lipids 1863:1274-1284
Sagona, Jessica A; Weisel, Clifford; Meng, Qingyu (2018) Accuracy and practicality of a portable ozone monitor for personal exposure estimates. Atmos Environ (1994) 175:120-126
Mauro, T; Hao, L; Pop, L C et al. (2018) Circulating zearalenone and its metabolites differ in women due to body mass index and food intake. Food Chem Toxicol 116:227-232
Fournier, S B; D'Errico, J N; Stapleton, P A (2018) Engineered nanomaterial applications in perinatal therapeutics. Pharmacol Res 130:36-43
Stapleton, P A; Hathaway, Q A; Nichols, C E et al. (2018) Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome. Part Fibre Toxicol 15:3

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