Goals and AimsOur goal is to establish a new Research Cluster to serve as a hub of intellectual activity to build innovativeenvironmental genomics into the EHSRC research portfolio and to serve as a resource that will facilitate thetransfer of knowledge, strategy and techniques to junior investigators beginning new programs andestablished investigators ready to incorporate genomics into existing EHSRC investigations. We will takeadvantage of successful efforts already in place on our campus with investigators who have a long standingexperience of genomics/genetics as well as the capability to provide leadership and guidance.The primary goal in building an environmental genomics research capability is to take advantage of thedevelopments in both laboratory techniques and analytical advances to provide a setting in whichinvestigators can add genetics/genomics to new or ongoing research programs. The initial publication ofhuman genome sequence in 2000 has been followed by a series of ever more startling developments thatprovide opportunities for individual and population based studies incorporating genetics on a scale thatexceeds even the most positive views of just a few years ago. DMA sequencing capabilities, geneexpression analysis, proteomics and genotype analysis are now all affordable on a genome scale to evenmodest size laboratory groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES005605-17
Application #
7359477
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2007-04-01
Project End
2012-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
17
Fiscal Year
2007
Total Cost
$28,993
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
P?n?íková, Kate?ina; Brenerová, Petra; Svržková, Lucie et al. (2018) Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25:16411-16419
Brandt, Kristin E; Falls, Kelly C; Schoenfeld, Joshua D et al. (2018) Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biol 14:82-87
Leelakanok, Nattawut; Geary, Sean M; Salem, Aliasger K (2018) Antitumor Efficacy and Toxicity of 5-Fluorouracil-Loaded Poly(Lactide Co-glycolide) Pellets. J Pharm Sci 107:690-697
Bao, Wei; Dar, Sharon; Zhu, Yeyi et al. (2018) Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes 10:487-495
Meyerholz, David K; Sieren, Jessica C; Beck, Amanda P et al. (2018) Approaches to Evaluate Lung Inflammation in Translational Research. Vet Pathol 55:42-52
Bodduluri, Sandeep; Reinhardt, Joseph M; Hoffman, Eric A et al. (2018) Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 15:281-289
Gergen, Peter J; Mitchell, Herman E; Calatroni, Agustin et al. (2018) Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population. J Allergy Clin Immunol Pract 6:101-107.e2
Haghighi, Babak; D Ellingwood, Nathan; Yin, Youbing et al. (2018) A GPU-based symmetric non-rigid image registration method in human lung. Med Biol Eng Comput 56:355-371
Liu, Buyun; Sun, Yangbo; Lehmler, Hans-Joachim et al. (2018) Association between urinary tin concentration and diabetes in nationally representative sample of US adults. J Diabetes 10:977-983
Oelsner, Elizabeth C; Smith, Benjamin M; Hoffman, Eric A et al. (2018) Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study. Thorax 73:486-488

Showing the most recent 10 out of 1123 publications