Since its inception in 1990, the Environmental Health Sciences Research Center (EHSRC) has advanced and translated research that addresses environmental health problems across the urban-rural continuum. The Center vision is to be the primary resource for improving the health of rural residents by stimulating and translating innovative environmental health sciences research. This is accomplished by gaining new insights into rural exposures;pathways of host defense, lung injury and repair;population health;and the toxicity of nanoscale materials;and, then translating these insights to clinical medicine, public health practice and regulatory policy. The Center goals are to: 1) Develop and expand innovative interdisciplinary environmental health sciences research in their core areas;2) Recruit, mentor and nurture talented new investigators in environmental health sciences;and 3) Provide outreach and engagement in an effort to translate research findings toward improving the health and environment of rural dwellers. The investigators interdisciplinary research is organized around four Research Cores: Inflammation &Innate Immunity, Oxidative Stress &Metabolism, Environmental Lung Disease and Nanotoxicology. Three Facility Cores provide cutting edge services and equipment: Integrative Health Sciences Facility, Pulmonary Toxicology Facility, and Environmental Modeling &Exposure Assessment Facility. The EHSRC is at the forefront of research on environmental health problems such as environmental lung diseases, bioaerosol-induced inflammation, mechanisms of oxidative stress, innate immune responses to inhaled microbial agents, and metabolism of pesticides and other chemical agents. An Administrative Core leverages institutional support and manages the state-of-the-art Facility Cores and highly effective Pilot Grant and Career Development Programs that provide resources and mentoring to advance the careers of promising young investigators. The Community Outreach and Engagement Core engages stakeholders in bi-directional communications to ensure relevance of EHSRC research and to translate research findings to environmental public health.

Public Health Relevance

The Environmental Health Sciences Research Center (EHSRC) serves to develop careers of environmental health scientists, advance environmental health research, and translate this research to stakeholders. EHSRC investigators are devoted to advancing current knowledge of rural environmental exposures and their health effects and to translating these findings in meaningful ways for the benefit of public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005605-23
Application #
8464702
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
1997-04-01
Project End
2017-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
23
Fiscal Year
2013
Total Cost
$1,547,572
Indirect Cost
$616,854
Name
University of Iowa
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
P?n?íková, Kate?ina; Svržková, Lucie; Strapá?ová, Simona et al. (2018) In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486
Andreotti, Gabriella; Koutros, Stella; Hofmann, Jonathan N et al. (2018) Glyphosate Use and Cancer Incidence in the Agricultural Health Study. J Natl Cancer Inst 110:509-516
Martinez, Carlos H; Li, Sara X; Hirzel, Andrew J et al. (2018) Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort. J Allergy Clin Immunol 141:429-432
Schoenfeld, Joshua D; Sibenaller, Zita A; Mapuskar, Kranti A et al. (2018) Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models. Redox Biol 14:417-422
P?n?íková, Kate?ina; Brenerová, Petra; Svržková, Lucie et al. (2018) Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25:16411-16419
Brandt, Kristin E; Falls, Kelly C; Schoenfeld, Joshua D et al. (2018) Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biol 14:82-87
Leelakanok, Nattawut; Geary, Sean M; Salem, Aliasger K (2018) Antitumor Efficacy and Toxicity of 5-Fluorouracil-Loaded Poly(Lactide Co-glycolide) Pellets. J Pharm Sci 107:690-697
Bao, Wei; Dar, Sharon; Zhu, Yeyi et al. (2018) Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes 10:487-495
Meyerholz, David K; Sieren, Jessica C; Beck, Amanda P et al. (2018) Approaches to Evaluate Lung Inflammation in Translational Research. Vet Pathol 55:42-52
Bodduluri, Sandeep; Reinhardt, Joseph M; Hoffman, Eric A et al. (2018) Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 15:281-289

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