9.1.2 Rationale for Goals and Aims The IHSF is a central component of the EHSRC, promoting human-centered research. An emphasis on human studies has been a long-standing strength of the EHSRC;this facility provides the infrastructure to conduct such studies with safety (to both research subjects and investigators), reproducibility, and rigorous scientific approaches. The IHSF supports radiological imaging, bronchoscopies, and other services needed to translate basic investigations into clinical studies. A significant change in the IHSF since our previous application has been driven by the awarding of a Clinical and Translational Science Award (CTSA) to the U.I. ICTS. This development has led to a significant (over $10 million) investment by the University into research infrastructure and facilities from which our EHSRC investigators can benefit. Although the ICST provides outstanding facilities available for human research, its strengths are centered on subject interactions;the IHSF provides support in specific research modalities, including human exposures, enhanced pulmonary function testing, bronchoscopy, and imaging for EHS-related research. We have enhanced the Center services to ensure that EHSRC researchers are able to maximize the potential for translational environmental health science research. Being able to access both ICTS resources as well as EHSRC facilities is a great opportunity for center investigators. We will support investigators using these state-of-the-art facilities by enhanced study design, IRB support, measurements, biological sampling. and specimen analyses. Furthermore, we will subsidize the costs of using the ICTS facilities. The University of Iowa ICST has initiated a policy of recharges for all studies. This is gradated by funding source, so that industry-initiated, industry-sponsored trials are charged the actual cost of providing services (including protocol review, document preparation, clinical services, etc), and NIH-funded studies are charged discounted fees, generally by 50%. Because we recognize that this cost-shifting will provide a barrier for new and non-funded investigators;to support our investigators, we propose to cover a substantial portion of this

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005605-23
Application #
8464721
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
23
Fiscal Year
2013
Total Cost
$215,783
Indirect Cost
$72,888
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Gibson-Corley, Katherine N; Meyerholz, David K; Engelhardt, John F (2016) Pancreatic pathophysiology in cystic fibrosis. J Pathol 238:311-20
Vacchi-Suzzi, Caterina; Karimi, Roxanne; Kruse, Danielle et al. (2016) Low-level mercury, omega-3 index and neurobehavioral outcomes in an adult US coastal population. Eur J Nutr 55:699-711
Anthony, T Renée; Sleeth, Darrah; Volckens, John (2016) Sampling efficiency of modified 37-mm sampling cassettes using computational fluid dynamics. J Occup Environ Hyg 13:148-58
Meyerholz, David K; Lambertz, Allyn M; Reznikov, Leah R et al. (2016) Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans. Toxicol Pathol 44:434-41
Li, Miao; Teesch, Lynn M; Murry, Daryl J et al. (2016) Cytochrome c adducts with PCB quinoid metabolites. Environ Sci Pollut Res Int 23:2148-59
Morris, Angie S; Adamcakova-Dodd, Andrea; Lehman, Sean E et al. (2016) Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs. Toxicol Lett 241:207-15
Wangpradit, Orarat; Rahaman, Asif; Mariappan, S V Santhana et al. (2016) Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids. Environ Sci Pollut Res Int 23:2138-47
Nalbandian, Michael J; Zhang, Miluo; Sanchez, Joel et al. (2016) Synthesis and optimization of Fe2O3 nanofibers for chromate adsorption from contaminated water sources. Chemosphere 144:975-81
Flor, Susanne; He, Xianran; Lehmler, Hans-Joachim et al. (2016) Estrogenicity and androgenicity screening of PCB sulfate monoesters in human breast cancer MCF-7 cells. Environ Sci Pollut Res Int 23:2186-200
Mudunkotuwa, Imali A; Anthony, T Renée; Grassian, Vicki H et al. (2016) Accurate quantification of tio2 nanoparticles collected on air filters using a microwave-assisted acid digestion method. J Occup Environ Hyg 13:30-9

Showing the most recent 10 out of 846 publications