This application requests a 5-year renewal of the Center for Environmental Genetics (CEG). The unifying research focus of the Center is to study the impact of genetic diversity on individual susceptibility to deleterious environmental agents. The CEG has a long 15-year history of accomplishments in environmental genetics that helps shape one of the nation's current top priorities in environmental health sciences (EHS) research. The investigators will expand their pioneering efforts and propose the following aims for the next funding period.
Aim 1 : To promote research in gene-environment interactions in human health and disease by emphasizing the use of environmental exposures in relationship with genetic variations and epigenetic reprogramming to inform pathophysiologic endpoints.
Aim 2 : To hasten translation of basic biomedical EHS research and population-based studies into clinical practices for disease prevention, diagnosis, and prognosis. Reciprocally, Center activities will afford opportunities for novel hypotheses to be generated from human based studies to be tested in laboratory settings.
Aim 3 : To foster the development of sensitive pathophysiological markers for the assessment of internal dose and improve measures of body burden;to undertake the discovery predictive makers so that the effects of early life exposure on later-life disease risk could be anticipated and minimized through innovative intervention measures. Validation of these markers through quantitative and qualitative measurements of phenotype or clinical outcomes will be an integral part of this aim.
Aim 4 : To attract and train the next generation of biomedical EHS investigators and clinicians with a strong desire to apply EHS in their clinical practices through partnership of the investigators'comprehensive Career Development Program (CDP) and a newly established Master Degree in Clinical Training program. A Pilot Project Program will function to continue support young investigators till they attain independence in EHS research, and to recruit new-to-EHS scientists. Three Facility/Service Cores will facilitate attainment of the goals: 1) the Integrative Technology Services Core will inject leading edge technologies into EHS research;2) the Integrative Health Services Core will help manage and share epidemiological and clinical databases, support tissue procurement, and development of clinical protocols;and 3) the Informatics Core will support all levels of data-mining and hypothesis-creation opportunities from various systems biology and clinical investigations. The overarching objective of the Center is to improve human health through effective integration of basic, clinical and epidemiological research, germane to gene-environment interaction, toward the ultimate goal of delivering """"""""personalized"""""""" medicine and devising public health initiatives for susceptible populations. The multiplicity of expertise and strong fund holding amongst membership, and the unyielding commitment from institution leadership constitute the elements of success in this application.
|DeFranco, Emily; Moravec, William; Xu, Fan et al. (2016) Exposure to airborne particulate matter during pregnancy is associated with preterm birth: a population-based cohort study. Environ Health 15:6|
|Ho, Shuk-Mei; Rao, Rahul C; To, Sarah et al. (2016) Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer. Endocr Relat Cancer :|
|Vuong, Ann M; Yolton, Kimberly; Webster, Glenys M et al. (2016) Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children. Environ Res 147:556-64|
|Chen, Szu-Hua; Meller, Jaroslaw; Elber, Ron (2016) Comprehensive analysis of sequences of a protein switch. Protein Sci 25:135-46|
|Yekeen, Taofeek Akangbe; Xu, Xijin; Zhang, Yuling et al. (2016) Assessment of health risk of trace metal pollution in surface soil and road dust from e-waste recycling area in China. Environ Sci Pollut Res Int 23:17511-24|
|Seachrist, Darcie D; Bonk, Kristen W; Ho, Shuk-Mei et al. (2016) A review of the carcinogenic potential of bisphenol A. Reprod Toxicol 59:167-82|
|Liu, Yanhong; Kheradmand, Farrah; Davis, Caleb F et al. (2016) Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. J Thorac Oncol 11:52-61|
|Sterkel, Alana K; Lorenzini, Jenna L; Fites, J Scott et al. (2016) Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity. Cell Host Microbe 19:361-74|
|Rebholz, Sandra L; Jones, Thomas; Herrick, Robert L et al. (2016) Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice. Toxicol Rep 3:46-54|
|Govindarajah, Vinothini; Leung, Yuet-Kin; Ying, Jun et al. (2016) In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands. J Nutr Biochem 29:73-82|
Showing the most recent 10 out of 867 publications